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Titolo:
Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis
Autore:
Leissner, J; Hohenfellner, R; Thuroff, JW; Wolf, HK;
Indirizzi:
Univ Mainz, Dept Urol, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 ainz, Dept Urol, D-55131 Mainz, Germany Univ Mainz, Dept Pathol, D-55131 Mainz, Germany Univ Mainz Mainz GermanyD-55131 nz, Dept Pathol, D-55131 Mainz, Germany
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 7, volume: 85, anno: 2000,
pagine: 817 - 823
SICI:
1464-4096(200005)85:7<817:LIPWTC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE DISSECTION; COLORECTAL-CARCINOMA; RADICAL CYSTECTOMY; GASTRIC-CANCER; BREAST-CANCER; FOLLOW-UP; CHEMOTHERAPY; RATIONALE; SURVIVAL;
Keywords:
urinary bladder; lymphadenectomy; lymph node; pathology; prognosis; transitional cell carcinoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Leissner, J Univ Mainz, Dept Urol, Langenbeckstr 1, D-55131 Mainz, GermanyUniv Mainz Langenbeckstr 1 Mainz Germany D-55131 inz, Germany
Citazione:
J. Leissner et al., "Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis", BJU INT, 85(7), 2000, pp. 817-823

Abstract

Objective To determine the need to standardize the number and location of lymph nodes to be removed during radical cystectomy in patients with invasive bladder carcinoma. Patients and methods The pelvic lymph nodes from 447 patients (mean age 62.8 years) who underwent radical cystectomy between 1986 and 1997 were evaluated. The number of lymph nodes was correlated with the depth of invasion of the primary tumour (pT), occurrence of nodal metastases, clinical outcome, the operating surgeons and the pathologists dissecting the nodes. Results The clinical follow-up was available for 302 patients (mean follow-up 38.7 months). The mean (range) number of lymph nodes removed was 14.7 (1-46). The number of lymph nodes removed varied significantly among different surgeons but not among pathologists. In pT3 and pT4 tumours, a more extended lymphadenectomy (greater than or equal to 16 lymph nodes) correlated with a higher percentage of patients with documented nodal metastases. Therewas a significant correlation between the number of lymph nodes removed and the tumour-free 5-year survival in patients with pT1, pT2 or pT3 tumours,and in patients with 1-5 positive lymph nodes (P < 0.01). Conclusion Extensive lymphadenectomy significantly improves the prognosis of patients with invasive bladder cancer and represents a potentially curative procedure in patients with nodal metastases, including micrometastases that may escape detection during routine histopathological evaluation. The results indicate the need for a standardized lymph node dissection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:27:51