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Titolo:
Lateral diffusion of membrane proteins in the presence of static and dynamic corrals: Suggestions for appropriate observables
Autore:
Brown, FLH; Leitner, DM; McCammon, JA; Wilson, KR;
Indirizzi:
Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 iochem, La Jolla, CA 92093 USA
Titolo Testata:
BIOPHYSICAL JOURNAL
fascicolo: 5, volume: 78, anno: 2000,
pagine: 2257 - 2269
SICI:
0006-3495(200005)78:5<2257:LDOMPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-PARTICLE TRACKING; FLUID MOSAIC MODEL; ERYTHROCYTE-MEMBRANE; PLASMA-MEMBRANE; SKELETON; BAND-3; MOBILITY; ASSOCIATION; BARRIER; NETWORK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Brown, FLH Univ Calif San Diego, Dept Chem & Biochem, M-S 0339, La Jolla, CA 92093 USA Univ Calif San Diego M-S 0339 La Jolla CA USA 92093 A 92093 USA
Citazione:
F.L.H. Brown et al., "Lateral diffusion of membrane proteins in the presence of static and dynamic corrals: Suggestions for appropriate observables", BIOPHYS J, 78(5), 2000, pp. 2257-2269

Abstract

We consider the possibility of inferring the nature of cytoskeletal interaction with transmembrane proteins via optical experiments such as single-particle tracking (SPT) and near-field scanning optical microscopy (NSOM). Inparticular, we demonstrate that it may be possible to differentiate between static and dynamic barriers to diffusion by examining the time-dependent variance and higher moments of protein population inside cytoskeletal "corrals. " Simulations modeling Band 3 diffusion on the surface of erythrocytes provide a concrete demonstration that these statistical tools might prove useful in the study of biological systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:16:49