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Titolo:
Prefrontal and medial temporal correlates of repetitive violence to self and others
Autore:
Critchley, HD; Simmons, A; Daly, EM; Russell, A; van Amelsvoort, T; Robertson, DM; Glover, A; Murphy, DGM;
Indirizzi:
Inst Psychiat, Dept Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 10, volume: 47, anno: 2000,
pagine: 928 - 934
SICI:
0006-3223(20000515)47:10<928:PAMTCO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; POSITRON EMISSION TOMOGRAPHY; MENTAL DISORDER; LOBE EPILEPSY; AGGRESSION; BEHAVIOR; BRAIN; SCHIZOPHRENIA; DYSFUNCTION; PSYCHOPATHS;
Keywords:
aggression; amygdala; hippocampus; mental impairment; prefrontal lobe; violence; spectroscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, DGM Inst Psychiat, Dept Psychol Med, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF England
Citazione:
H.D. Critchley et al., "Prefrontal and medial temporal correlates of repetitive violence to self and others", BIOL PSYCHI, 47(10), 2000, pp. 928-934

Abstract

Background: The neurobiological basis for violence in humans is poorly understood, yet violent behavior (to self or others) is associated with large social and healthcare costs in some groups of patients (e.g., the mentally retarded). The prefrontal cortex and amygdalo-hippocampal complex (AHC) areimplicated in the control aggression, therefore we examined the neural integrity of these regions in violent patients with mild mental retardation and nonviolent control subjects. Methods: We used H-1-magnetic resonance spectroscopy (MRS) to measure 1) concentrations and ratios of N-acetyl aspartate (NAA), creatine phosphocreatine (Cr+PCr), and choline-related compounds (Cho) in prefrontal lobe of 10 violent inpatients and 8 control subjects; 2) ratios of NAA, Cr+PCr, and Cho in the AHC of 13 inpatients and 14 control subjects; and 3) frequency andseverity of violence in patients. Results: Compared to control subjects, violent patients had significantly (p < .05, analysis of covariance-age and IQ as confounding covariates) lower prefrontal concentrations of NAA and Cr+PCr, and a lower ratio of NAA/Cr+PCr in the AHC. Within the violent patient group, frequency of observed violence to others correlated significantly with prefrontal lobe NAA concentration (r = -0.72, p < .05). Conclusions: NAA concentration indicates neuronal density, and Cr+PCr concentration high-energy phosphate metabolism. Our findings suggest that violent patients with mild mental retardation have reduced neuronal density, andabnormal phosphate metabolism in prefrontal lobe and AHC compared to nonviolent control subjects. Further studies are needed, however, to determine if these findings are regionally specific, or generalize to other groups of violent individuals. (C) 2000 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 05:56:05