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Titolo:
Plasma neuropeptide-Y concentrations in humans exposed to military survival training
Autore:
Morgan, CA; Wang, S; Southwick, SM; Rasmusson, A; Hazlett, G; Hauger, RL; Charney, DS;
Indirizzi:
VA Connecticut Healthcaare Syst, Natl Ctr PTSD Anxiety Clin, W Haven, CT 06516 USA VA Connecticut Healthcaare Syst W Haven CT USA 06516 Haven, CT 06516 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA Yale Univ New Haven CT USA iv, Sch Med, Dept Psychiat, New Haven, CT USA JFK Special Warfare Training Ctr & Sch, Fort Bragg, NC USA JFK Special Warfare Training Ctr & Sch Fort Bragg NC USA t Bragg, NC USA Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 Med, San Diego, CA 92103 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 10, volume: 47, anno: 2000,
pagine: 902 - 909
SICI:
0006-3223(20000515)47:10<902:PNCIHE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; SYMPATHETIC ACTIVATION; RECEPTOR AGONISTS; CORTISOL-LEVELS; PEPTIDE-YY; STRESS; IMMUNOREACTIVITY; CATECHOLAMINES; MODULATION; RESPONSES;
Keywords:
military stress; stess resilience; PTSD; Special Forces; cortisol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Morgan, CA VA Connecticut Healthcaare Syst, Natl Ctr PTSD Anxiety Clin, W Haven, CT 06516 USA VA Connecticut Healthcaare Syst W Haven CT USA 06516 06516 USA
Citazione:
C.A. Morgan et al., "Plasma neuropeptide-Y concentrations in humans exposed to military survival training", BIOL PSYCHI, 47(10), 2000, pp. 902-909

Abstract

Background: Neuropeptide-Y (NPY) is present in extensive neuronal systems of the brain and is present in high concentrations in cell bodies and terminals in the amygdala, Preclinical studies have shown that injections of NPYinto the central nucleus of the amygdala function as a central anxiolytic and buffer against the effects of stress. The objective of this study was to assess plasma NPY immunoreactivity in healthy soldiers participating in high intensity military training at the U.S. Army survival school. The Army survival school provides a means of observing individuals under high levelsof physical, environmental, and psychological stress, and consequently is considered a reasonable analogue to stress incurred as a result of war or other catastrophic experiences. Methods: Plasma levels of NPY were assessed at baseline (prior to initiation of training), and 24 hours after the conclusion of survival training in 49 subjects, and at baseline and during the Prisoner of War (P.O.W) experience (immediately after exposure to a military interrogation) in 21 additional subjects. Results: Plasma NPY levels were significantly increased compared to baseline following interrogations and were significantly higher in Special Forcessoldiers, compared to non-Special Forces soldiers. NPY elicited by interrogation stress was significantly correlated to the subjects' behavior duringinterrogations and tended so be negatively correlated to symptoms of reported dissociation. Twenty-four hours after the conclusion of survival training, NPY had returned to baseline in Special Forces soldiers, but remained significantly lower than baseline values in non-Special Forces soldiers. NPYwas positively correlated with both cortisol and behavioral performance under stress. NPY was negatively related to psychological symptoms of dissociation. Conclusions: These results provide evidence that uncontrollable stress significantly increases plasma NPY in humans, and when extended, produces a significant depletion of plasma NPY. Stress-induced alterations of plasma NPYwere significantly different in Special Forces soldiers compared to non-Special Forces soldiers. These data support the idea that NPY may be involvedin the enhanced stress resilience seen in humans.

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Documento generato il 20/01/20 alle ore 21:59:09