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Titolo:
The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma
Autore:
Behrends, S; Vehse, K;
Indirizzi:
Univ Hamburg, Inst Pharmakol, D-20251 Hamburg, Germany Univ Hamburg Hamburg Germany D-20251 Pharmakol, D-20251 Hamburg, Germany
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 271, anno: 2000,
pagine: 64 - 69
SICI:
0006-291X(20000429)271:1<64:TBSOSG>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; NITRIC-OXIDE; RAT-KIDNEY; GENES; HYBRIDIZATION; ASSIGNMENT; PRIMATES; ALPHA(1); GUCY1B2; TUMORS;
Keywords:
soluble gaunylyl cyclase; nitric oxide; cyclic GMP; primates; evolution;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Behrends, S Univ Hosp Eppendorf, Inst Pharmakol, Martinistr 52, D-20251 Hamburg, Germany Univ Hosp Eppendorf Martinistr 52 Hamburg Germany D-20251 any
Citazione:
S. Behrends e K. Vehse, "The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma", BIOC BIOP R, 271(1), 2000, pp. 64-69

Abstract

Soluble or nitric oxide (NO) stimulated guanglyl cyclases are obligate heme-containing heterodimers (alpha/ beta). We report the full-length cDNA of the human ortholog of the rat beta(2)-subunit from human kidney. A databasesearch yielded matches of the 3' non-coding sequence with previously unassigned expressed sequence tags from kidney and stomach signet ring cell carcinoma. PCR comparison of cDNA from stomach signet ring cell carcinoma and normal stomach tissue demonstrated beta(2) subunit expression in cancer but not in normal tissue. On the cDNA level a frameshift deletion of one nucleotide was present in the novel human sequence which was confirmed on the genomic DNA level, In four closely related nonhuman primate species the frameshift deletion was absent while analysis of genomic DNA from different ethnic backgrounds revealed the uniform presence of the frameshift deletion in the human population. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:53:08