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Titolo:
Gender related association between genetic variations of APOC-III gene andlipid and lipoprotein variables in northern France
Autore:
Dallongeville, J; Meirhaeghe, A; Cottel, D; Fruchart, JC; Amouyel, P; Helbecque, N;
Indirizzi:
Inst Pasteur, Serv Epidemiol & Sante Publ, INSERM, U508, F-59019 Lille, France Inst Pasteur Lille France F-59019 l, INSERM, U508, F-59019 Lille, France Inst Pasteur, Dept Atherosclerose, F-59019 Lille, France Inst Pasteur Lille France F-59019 Atherosclerose, F-59019 Lille, France Inst Pasteur, INSERM, U325, F-59019 Lille, France Inst Pasteur Lille France F-59019 r, INSERM, U325, F-59019 Lille, France
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 150, anno: 2000,
pagine: 149 - 157
SICI:
0021-9150(200005)150:1<149:GRABGV>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL COMBINED HYPERLIPIDEMIA; APOLIPOPROTEIN-C-III; FRAGMENT-LENGTH POLYMORPHISMS; A-I/C-III; PLASMA-LIPOPROTEINS; CIII GENE; MYOCARDIAL-INFARCTION; DNA POLYMORPHISMS; LIPASE GENE; CLUSTER;
Keywords:
apolipoprotein C-III; triglycerides; cholesterol; lipoproteins; hypertriglyceridemia; hypercholesterolemia; dyslipidemia; genetics; polymorphism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Dallongeville, J Inst Pasteur, Serv Epidemiol & Sante Publ, INSERM, U508, 1 Rue Prof Calmette, F-59019 Lille, France Inst Pasteur 1 Rue Prof CalmetteLille France F-59019 ce
Citazione:
J. Dallongeville et al., "Gender related association between genetic variations of APOC-III gene andlipid and lipoprotein variables in northern France", ATHEROSCLER, 150(1), 2000, pp. 149-157

Abstract

The goal of the present study was to assess the impact of variability at the APOC-III insulin response element (APOC-III IRE) genetic locus on lipid,lipoprotein and complex lipoprotein particle levels as well as on the riskof dyslipidemia, in the population of northern France. To this end, 590 men and 579 women were randomly selected in the urban community of Lille in the framework of the MONICA project. Three polymorphisms, - 482, - 455 in the APOC-III insulin response element (IRE) and SstI in the 3'-noncoding region of the APOC-III gene locus were assessed. Compared to the most common alleles, the rare alleles of -482 and -455 were associated with increased levels of apoB-containing particles (LDL-cholesterol, apoB) and of triglyceride-related markers (apoC-III and LpC-III:B) in women, but not in men, suggesting a gender-related impact of APOC-III polymorphisms on these variables. Similarly, triglycerides, LpC-III:B and apoB were higher in women bearing the rare allele of SstI than in those with the most common allele. There wasno evidence for any significant association between any of the - 482, - 455, and SstI alleles and lipid disorders (mixed hyperlipidemia, hypertriglyceridemia and hypercholesterolemia) in this sample of randomly selected men and women from northern France. In contrast, the prevalence of the haplotype that combined the rare alleles of the - 482 and -455 sites was increased only in women with hypertriglyceridemia. Therefore, although the individualrisk of hypertriglyceridemia is increased in women with the haplotype T, Cat -482, -455, it appears that the -482, -455 and SstI APOC-III gene polymorphisms are not major contributors to the risk of dyslipidemia in the population of northern France. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:58:37