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Titolo:
Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis - Findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1
Autore:
Andersen, GN; Caidahl, K; Kazzam, E; Petersson, AS; Waldenstrom, A; Mincheva-Nilsson, L; Rantapaa-Dahlqvist, S;
Indirizzi:
Univ Umea Hosp, S-90185 Umea, Sweden Univ Umea Hosp Umea Sweden S-90185Univ Umea Hosp, S-90185 Umea, Sweden Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden S-41345 S-41345 Gothenburg, Sweden
Titolo Testata:
ARTHRITIS AND RHEUMATISM
fascicolo: 5, volume: 43, anno: 2000,
pagine: 1085 - 1093
SICI:
0004-3591(200005)43:5<1085:CBINOP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; LUPUS-ERYTHEMATOSUS; UP-REGULATION; PLASMINOGEN-ACTIVATOR; PERIPHERAL-BLOOD; INTERFERON-GAMMA; DISEASE-ACTIVITY; FACTOR-ALPHA; SCLERODERMA; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Rantapaa-Dahlqvist, S Dept Rheumatol, SE-90185 Umea, Sweden Dept Rheumatol Umea Sweden SE-90185 5 Umea, Sweden
Citazione:
G.N. Andersen et al., "Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis - Findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1", ARTH RHEUM, 43(5), 2000, pp. 1085-1093

Abstract

Objective. To determine the relationship between vascular function and theinflammatory response in systemic sclerosis (SSc), and to investigate whether production of endothelial-derived nitric oxide (NO) is disturbed in this disease. Methods. We measured plasma nitrate, urinary excretion of both nitrate andcGMP, and soluble adhesion molecules of endothelial origin in patients with SSc and in age- and sex-matched controls and compared these levels between groups. Additionally, we performed correlation analysis to determine how these variables were related to one another, Plasma nitrate and 24-hour-urinary excretion of nitrate in patients and controls were measured after a 72-hour nitrate-free-diet, using a gas chromatography/mass spectrometric method. Soluble adhesion molecules intercellular adhesion molecule 1 (sICAM-1),vascular cell adhesion molecule 1 (sVCAM-1), and E-selectin and cytokines were measured by enzyme-linked immunosorbent assay. The expression of E-selectin was further investigated in skin biopsy specimens by immunoperoxidasestaining, and the presence of inducible NO synthase by immunoblotting. Results. Plasma nitrate and 24-hour-urinary-excretion of cGMP were significantly elevated in patients compared with controls, while 24-hour-urinary-excretion of nitrate tended to be elevated in SSc patients. Levels of sICAM-1, sVCAM-1, and sE-selectin were significantly elevated in the patients. Levels of plasma nitrate in the patients correlated significantly with levelsof sVCAM-1 (P = 0.020) and sE-selectin (P = 0.018) and approached a significant correlation with sICAM-1 (P = 0.055), suggesting that activated endothelial cells may produce plasma nitrate. Conclusion. NO synthesis is elevated in SSc patients, and the activated endothelial cell is a likely site of its production.

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Documento generato il 27/11/20 alle ore 02:26:57