Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of borage oil consumption on fatty acid metabolism, transepidermal water loss and skin parameters in elderly people
Autore:
Brosche, T; Platt, D;
Indirizzi:
Univ Erlangen Nurnberg, Inst Gerontol, D-90419 Nurnberg, Germany Univ Erlangen Nurnberg Nurnberg Germany D-90419 -90419 Nurnberg, Germany
Titolo Testata:
ARCHIVES OF GERONTOLOGY AND GERIATRICS
fascicolo: 2, volume: 30, anno: 2000,
pagine: 139 - 150
SICI:
0167-4943(200003/04)30:2<139:EOBOCO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYME PREPARATIONS; RATS; AGE;
Keywords:
aged; borage oil; gamma linolenic acid; dietary supplementation; skin; transepidermal water loss; skin dryness; itch; erythrocyte membranes; fatty acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Brosche, T Univ Erlangen Nurnberg, Inst Gerontol, Heimerichstr 58, D-90419Nurnberg, Germany Univ Erlangen Nurnberg Heimerichstr 58 Nurnberg GermanyD-90419
Citazione:
T. Brosche e D. Platt, "Effect of borage oil consumption on fatty acid metabolism, transepidermal water loss and skin parameters in elderly people", ARCH GER G, 30(2), 2000, pp. 139-150

Abstract

Human skin is not able to biosynthesize gamma-linolenic acid (GLA, 18:3 omega 6) from the precursor linoleic acid (LA), or arachidonic acid (AA) fromdihomo-gamma-linolenic acid (DHGLA). Dietary supplementation with GLA-richseed oil of borage skips the step of hepatic 6-desaturation of fatty acids(FA) and, therefore, compensates the lack of these essential FA in conditions with impaired activity of delta 6-desaturase. Twenty-nine healthy elderly people (mean age 68.6 years), received a daily dose of 360 or 720 mg GLAfor 2 months, using Borage oil in gelatine capsules (Quintesal(R)180, manufacturer Galderma Laboratorium GmbH, Freiburg, Germany). The effects of fatty acids derived from ingested borage oil capsules on skin barrier functionwere assessed by measurement of transepidermal water loss (TEWL). The consumption of borage oil induced a statistically significant improvement of cutaneous barrier function in the elderly people, as reflected in a mean decrease of 10.8% in the transepidermal water loss. Thirty-four percent of the people noted itch before borage oil consumption and 0% afterwards. Dry skinwas claimed to be reduced from 42 to 14%, but no significant alteration ofskin hydration was measured. The FA-composition of erythrocyte membrane phospholipids demonstrated an increase of GLA (+70%) and DHGLA (+18%) and a reduction of saturated and monounsaturated FA. There was no significant alteration in nervonic acid or in AA content, but an increase in the DHGLA/AA ratio (+23%). Thus, the consumption of borage oil by elderly people lead to alteration of FA metabolism and improved skin function. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:56:15