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Titolo:
Cardiovascular diseases, health status, brain imaging findings and neuropsychological functioning in neurologically healthy elderly individuals
Autore:
Ylikoski, R; Ylikoski, A; Raininko, R; Keskivaara, P; Sulkava, R; Tilvis, R; Erkinjuntti, T;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Neuropsychol Unit, Helsinki 00029, Finland Univ Helsinki Helsinki Finland 00029 ychol Unit, Helsinki 00029, Finland Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Memory Res Unit, Helsinki, Finland Univ Helsinki Helsinki Finland osci, Memory Res Unit, Helsinki, Finland Uppsala Univ, Dept Radiol, Uppsala, Sweden Uppsala Univ Uppsala SwedenUppsala Univ, Dept Radiol, Uppsala, Sweden Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 ol, FIN-00014 Helsinki, Finland Univ Kuopio, Dept Publ Hlth & Gen Practice 6, Kuopio, Finland Univ KuopioKuopio Finland Publ Hlth & Gen Practice 6, Kuopio, Finland Univ Helsinki, Cent Hosp, Dept Geriatr, Helsinki, Finland Univ Helsinki Helsinki Finland nt Hosp, Dept Geriatr, Helsinki, Finland
Titolo Testata:
ARCHIVES OF GERONTOLOGY AND GERIATRICS
fascicolo: 2, volume: 30, anno: 2000,
pagine: 115 - 130
SICI:
0167-4943(200003/04)30:2<115:CDHSBI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COGNITIVE FUNCTION; BLOOD-PRESSURE; RISK-FACTORS; CEREBROVASCULAR-DISEASE; HYPERTENSIVE SUBJECTS; SUBCORTICAL LESIONS; ATRIAL-FIBRILLATION; OLD-AGE; PERFORMANCE; DEMENTIA;
Keywords:
aging; neuropsychology; health; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Ylikoski, R Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Neuropsychol Unit, POB 300, Helsinki 00029, Finland Univ Helsinki POB 300 Helsinki Finland00029 i 00029, Finland
Citazione:
R. Ylikoski et al., "Cardiovascular diseases, health status, brain imaging findings and neuropsychological functioning in neurologically healthy elderly individuals", ARCH GER G, 30(2), 2000, pp. 115-130

Abstract

The aim of our study was to evaluate the relationship between health-related factors, brain imaging findings and cognitive functioning. We examined 113 neurologically healthy subjects from 55 to 85 years of age. Health-related variables included a clinical health evaluation, cardiovascular diseases, and other systemic diseases. The presence of white matter changes and cerebral and peripheral atrophy were obtained with magnetic resonance imaging. Neuropsychological tests measuring verbal memory, visual memory, intellectual and language functions, visuoconstructional functions, flexibility, andspeed and attention were administered. Results showed that overall health status was not related to cognition. Subjects, who had both arterial hypertension and white matter changes had difficulties in flexibility. Cardiac failure and white matter changes were related to impairment in visuoconstructional functions, flexibility and attention. Significant speed and attentiondeficits were observed in subjects with cardiac failure and central atrophy. In conclusion, this study verifies the relationship between hypertension, white matter changes and cognitive functions. We found also specific patterns in relation with cardiac failure, brain imaging findings and cognitivefunctioning, the most vulnerable domains were visuoconstructional functions. flexibility and attention. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 25/11/20 alle ore 07:40:40