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Titolo:
Volumetric measure of the frontal and temporal lobe regions in schizophrenia - Relationship to negative symptoms
Autore:
Sanfilipo, M; Lafargue, T; Rusinek, H; Arena, L; Loneragan, C; Lautin, A; Feiner, D; Retrosen, J; Wolkin, A;
Indirizzi:
New York Vet Affairs Med Ctr, Psychiat Serv, New York, NY USA New York VetAffairs Med Ctr New York NY USA hiat Serv, New York, NY USA New York Vet Affairs Med Ctr, Serv Radiol, New York, NY USA New York Vet Affairs Med Ctr New York NY USA rv Radiol, New York, NY USA New York Vet Affairs Med Ctr, Magnet Resonance Imaging Sect, New York, NY USA New York Vet Affairs Med Ctr New York NY USA ging Sect, New York, NY USA NYU, Sch Med, Dept Psychiat, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Psychiat, New York, NY USA NYU, Sch Med, Dept Radiol, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Radiol, New York, NY USA Bellevue Hosp Ctr, Dept Psychiat, New York, NY 10016 USA Bellevue Hosp Ctr New York NY USA 10016 Psychiat, New York, NY 10016 USA Bellevue Hosp Ctr, Dept Radiol, New York, NY 10016 USA Bellevue Hosp Ctr New York NY USA 10016 pt Radiol, New York, NY 10016 USA
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 5, volume: 57, anno: 2000,
pagine: 471 - 480
SICI:
0003-990X(200005)57:5<471:VMOTFA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL GRAY-MATTER; PREFRONTAL CORTEX; WHITE-MATTER; CORTICAL GRAY; SUBCORTICAL DEMENTIA; BRAIN MORPHOLOGY; HIPPOCAMPAL VOLUME; RESONANCE; DEFICITS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Wolkin, A Vet Adm New York Harbor Hlth Care Syst, Mental Hlth Serv 11M, Room 17017W,423 E 23rd St, New York, NY 10010 USA Vet Adm New York Harbor Hlth Care Syst Room 17017W,423 E 23rd St New York NY USA 10010
Citazione:
M. Sanfilipo et al., "Volumetric measure of the frontal and temporal lobe regions in schizophrenia - Relationship to negative symptoms", ARCH G PSYC, 57(5), 2000, pp. 471-480

Abstract

Background: Previous research has provided evidence for bi-ain abnormalities in schizophrenia, but their relationship to specific clinical symptoms and syndrome remains unclear. Methods: With an all-male dermographically similar sample of 53 schizophrenic patients and 29 normal control subjects, cerebral gray and white mattervolumes (adjusted for intracranial volume and age) were determined for regions in the prefrontal lobe and in the superficial and mesial temporal lobeusing T1-weighted magnetic resonance imaging with 2.8-mm coronal slices. Results: As a group schizophrenic patients had widespread bilateral decrements in gray matter in the prefrontal (7.4%) and temporal lobe regions (8.9%), but not in white matter in these regions. In the temporal lobe, gray matter reductions were found bilaterally in the superior temporal gyrus (6.0%), but not in the hippocampus anti parahippocampus. While there were no overall group differences in white matter volumes, widespread decrements in prefrontal white matter in schizophrenic patients (n = 53) were related to higher levels of negative symptoms (partial r[49] = -0.42, P =.002), as measured by the Scale for the Assessment of Negative Symptoms. A post hoc analysis revealed that schizophrenic patients with high negative symptoms had generalized prefrontal white matter reductions (11.4%) that were most severe in the orbitofrontal subregion (15.1%). Conclusions: These results suggest that gray matter deficits may be a fairly common structural abnormality of schizophrenia, whereas reductions in prefrontal white matter Ina! bt associated with schizophrenic negative symptoms.

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Documento generato il 21/09/20 alle ore 16:58:07