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Titolo:
A comparative study of simple methods to quantify cerebral blood flow withacetazolamide challenge by using iodine-123-IMP SPECT with one-point arterial sampling
Autore:
Ohkubo, M; Odano, I;
Indirizzi:
Niigata Univ, Fac Med, Sch Hlth Sci, Dept Radiol Technol, Niigata 9518518,Japan Niigata Univ Niigata Japan 9518518 Radiol Technol, Niigata 9518518,Japan Niigata Univ, Sch Med, Dept Radiol, Niigata 95021, Japan Niigata Univ Niigata Japan 95021 Med, Dept Radiol, Niigata 95021, Japan
Titolo Testata:
ANNALS OF NUCLEAR MEDICINE
fascicolo: 2, volume: 14, anno: 2000,
pagine: 115 - 120
SICI:
0914-7187(200004)14:2<115:ACSOSM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTITION-COEFFICIENT; MICROSPHERE MODEL; HUMAN-BRAIN; IODINE-123-IODOAMPHETAMINE; N-ISOPROPYL-P-IODOAMPHETAMINE; IODOAMPHETAMINE; QUANTIFICATION; VALIDATION; TOMOGRAPHY; WASHOUT;
Keywords:
iodine-123-IMP; regional cerebral blood flow; SPECT; acetazolamide; compartment analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ohkubo, M Niigata Univ, Fac Med, Sch Hlth Sci, Dept Radiol Technol, 2-746 AsahimachiDori, Niigata 9518518, Japan Niigata Univ 2-746 Asahimachi Dori Niigata Japan 9518518 Japan
Citazione:
M. Ohkubo e I. Odano, "A comparative study of simple methods to quantify cerebral blood flow withacetazolamide challenge by using iodine-123-IMP SPECT with one-point arterial sampling", ANN NUCL M, 14(2), 2000, pp. 115-120

Abstract

The aim of this study was to compare the accuracy of simplified methods for quantifying rCBF with acetazolamide challenge by using I-123-N-isopropyl-p-iodoamphetamine (IMP) and SPECT with one-point arterial sampling. After acetazolamide administration we quantified rCBF in 12 subjects by the following three methods: (a) the modified microsphere method, (b) the IMP-autoradiographic (ARG) method based on a two-compartment one-parameter model, and (c) the simplified method based on a two-compartment two-parameter model (functional IMP method). The accuracy of these methods was validated by comparing rCBF values with those obtained by the standard method: the super-early microsphere method with continuous withdrawal of arterial blood. On analyzing rCBF in each flow range (0-0.25, 0.25-0.5, 0.5-0.75 and more than 0.75ml/g/min), rCBF values obtained by both methods (a) and (c) showed significant correlations (p < 0.01) with those obtained by the standard method in every range, but rCBF values obtained by method (b) did not significantly correlated in the high flow range (0.5-0.75 and more than 0.75 ml/g/min). Method (c) was found to be the most accurate, even though it needs two serialSPECT scans. When requiring one SPECT scan, method (a) was considered to be superior to method (b) because of its accuracy, especially in high flow regions loaded with acetazolamide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:47:53