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Titolo:
Identification and role of aldosterone receptors in the cardiovascular system
Autore:
Lombes, M; Farman, N; Bonvalet, JP; Zennaro, MC;
Indirizzi:
Fac Med Xavier Bichat, INSERM, U478, F-75870 Paris 18, France Fac Med Xavier Bichat Paris France 18 RM, U478, F-75870 Paris 18, France
Titolo Testata:
ANNALES D ENDOCRINOLOGIE
fascicolo: 1, volume: 61, anno: 2000,
pagine: 41 - 46
SICI:
0003-4266(200002)61:1<41:IAROAR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; HUMAN MINERALOCORTICOID RECEPTOR; RENIN-ANGIOTENSIN SYSTEM; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; CARDIAC FIBROSIS; BINDING-SITES; HUMAN HEART; RAT-HEART; HYPERTENSION; DETERMINANTS;
Keywords:
nuclear receptors; heart; blood vessels; mineralocorticoid; myocardiac function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Lombes, M Fac Med Xavier Bichat, INSERM, U478, IFR02,16 Rue Henri Huchard,F-75870 Paris 18, France Fac Med Xavier Bichat IFR02,16 Rue Henri Huchard Paris France 18
Citazione:
M. Lombes et al., "Identification and role of aldosterone receptors in the cardiovascular system", ANN ENDOCR, 61(1), 2000, pp. 41-46

Abstract

The cardiovascular system is now recognized as an important mineralocorticoid target. All components required for specific and selective aldosterone effects are present in the cardiovascular system. Mineralocorticoid receptors (MR) are expressed in the heart and large blood vessels together with the 11 beta-hydroxysteroid dehydrogenase type II, which ensures the enzymaticprotection of MR against glucocorticoids. The recent description of local vascular and cardiac aldosterone biosynthesis strongly supports an autocrine/paracrine hormonal action. Establishment of transgenic mice models of targeted overexpression of the mineralocorticoid receptor should facilitate new insights into the molecular and cellular mechanisms of aldosterone actions in the cardiovascular system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:50:04