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Titolo:
Factors related to methacholine airway responsiveness in children
Autore:
Ownby, DR; Peterson, EL; Johnson, CC;
Indirizzi:
Med Coll Georgia, Dept Pediat, Sect Allergy & Immunol, Augusta, GA 30921 USA Med Coll Georgia Augusta GA USA 30921 gy & Immunol, Augusta, GA 30921 USA Henry Ford Hlth Syst, Dept Epidemiol & Biostat, Detroit, MI USA Henry FordHlth Syst Detroit MI USA Epidemiol & Biostat, Detroit, MI USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 5, volume: 161, anno: 2000,
pagine: 1578 - 1583
SICI:
1073-449X(200005)161:5<1578:FRTMAR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL RESPONSIVENESS; LUNG-FUNCTION; YOUNG-ADULTS; SERUM IGE; POPULATION; SYMPTOMS; ASTHMA; HYPERRESPONSIVENESS; SCHOOLCHILDREN; HISTAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ownby, DR Med Coll Georgia, Dept Pediat, Sect Allergy & Immunol, CK 165, Augusta, GA30921 USA Med Coll Georgia CK 165 Augusta GA USA 30921 ugusta, GA30921 USA
Citazione:
D.R. Ownby et al., "Factors related to methacholine airway responsiveness in children", AM J R CRIT, 161(5), 2000, pp. 1578-1583

Abstract

Studies of airway responsiveness (AR) have typically used similar dose schedules of methacholine for adults and children despite large ranges in subject size. Reported declines in AR with increasing age in children could be due to maturational changes or to proportionately smaller doses of methacholine in taller (older) children. Other investigators have related both height and various measures of lung function to AR. We examined data related toAR in 471 children, aged 6 to 8 yr, from a birth cohort. Each child underwent spirometry followed by sequential challenge with five doses of methacholine, ranging from 0.025 to 25 mg/ml, given with a dosimeter. Continuous slope and end FEV1-change indexes of responsiveness were computed. Using stepwise regression modeling, we found no significant association between AR and either height or age after entering a variable reflecting asthma or wheezing, in contrast, we found that baseline measures of FVC, FEV1/FVC, and FEF25-75% were significantly related to AR after controlling for other variables (p = 0.001). However, when all three of the latter measures were added to models, FEF25-75% was most closely related to AR We conclude that after control for other variables, FEF25-75% and FVC, but not height, are significantly related to methacholine responsiveness in children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 11:35:49