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Titolo:
Hypertension and arterial stiffness: The atherosclerosis risk in communities study
Autore:
Arnett, DK; Boland, LL; Evans, GW; Riley, W; Barnes, R; Tyroler, HA; Heiss, G;
Indirizzi:
Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55454 USA Univ Minnesota Minneapolis MN USA 55454 demiol, Minneapolis, MN 55454 USA Bowman Gray Sch Med, Dept Publ Hlth, Winston Salem, NC USA Bowman Gray SchMed Winston Salem NC USA ubl Hlth, Winston Salem, NC USA ARIC Ultrasound Reading Ctr, Winston Salem, NC USA ARIC Ultrasound ReadingCtr Winston Salem NC USA , Winston Salem, NC USA Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA , Dept Epidemiol, Chapel Hill, NC USA
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 4, volume: 13, anno: 2000,
parte:, 1
pagine: 317 - 323
SICI:
0895-7061(200004)13:4<317:HAASTA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; ULTRASONIC MEASUREMENT; SYSTOLIC HYPERTENSION; BLOOD-PRESSURE; DISTENSIBILITY; ELASTICITY;
Keywords:
hypertension; arterial stiffness; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Arnett, DK Univ Minnesota, Sch Publ Hlth, Div Epidemiol, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA Univ Minnesota 1300 S 2nd St,Suite 300 Minneapolis MN USA 55454
Citazione:
D.K. Arnett et al., "Hypertension and arterial stiffness: The atherosclerosis risk in communities study", AM J HYPERT, 13(4), 2000, pp. 317-323

Abstract

Our objective was to describe the relationship of arterial stiffness and hypertension in a large, population-based sample of men and women. Hypertension-related increases in arterial stiffness may reflect the distending pressure and/or structural alterations in the artery. Included were 10,712 participants, ages 45 to 64 years, of the Atherosclerosis Risk in Communities Study, free of prevalent cardiovascular disease. Hypertension was classifiedas systolic or diastolic blood pressure (BP) greater than or equal to 140/90 mm Hg, respectively, or the current use of antihypertensive medications. Common carotid arterial diameter change was measured using B-mode ultrasound and an electronic device that utilized radio frequency signals to track the motion of the arterial walls. Using statistical models to control for diastolic BP and pulse pressure, arterial diameter change was calculated separately in normotensive/nonmedicated and medicated hypertensives. Hypertension was associated with a smalleradjusted diameter change (ie., greater stiffness) in comparison to optimalblood pressure (BP < 120/80 mm Hg): normotensive/nonmedicated men, 0.33 versus 0.43 mm (P < 0.001); medicated men, 0.34 versus 0.42 mm (P < 0.001); normotensive/nonmedicated women, 0.34 versus 0.40 mm (P < 0.001), and medicated women, 0.33 versus 0.40 mm (P < 0.001). The relationship between pulse pressure and diameter change (ie, the slope of pulse pressure and diameter change) did not differ between hypertensives and normotensives. These cross-sectional data suggest that hypertension is associated with carotid arterial stiffness; however, these differences in the calculated stiffness appear to be the effect of distending pressure rather than structuralchanges in the carotid artery. (C) 2000 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:23:06