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Titolo:
Arcuate nucleus of hypothalamus involved in analgesic action of l-THP
Autore:
Hu, JY; Jin, GZ;
Indirizzi:
Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 200031, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 5, volume: 21, anno: 2000,
pagine: 439 - 444
SICI:
0253-9756(200005)21:5<439:ANOHII>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIAQUEDUCTAL GRAY; DESCENDING PATHWAY; ACCUMBENS; TETRAHYDROPROTOBERBERINES; HABENULA;
Keywords:
tetrahydropalmatine; horseradish peroxidase; arcuate nucleus; PAG; corpus striatum; nucleus accumbens; analgesia; naloxone; endorphins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Jin, GZ Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China Chinese Acad Sci Shanghai Peoples R China 200031 Peoples R China
Citazione:
J.Y. Hu e G.Z. Jin, "Arcuate nucleus of hypothalamus involved in analgesic action of l-THP", ACT PHAR SI, 21(5), 2000, pp. 439-444

Abstract

AIM: To study the role of the arcuate nucleus of hypothalamus in analgesicaction of l-tetrahydropalmatine ( I-THP). METHODS: The horseradish peroxidase (HRP) retrograde tracing, HRP retrograde tracing combined with immunohistochemistry, lesion of nucleus, tail- flick test, and intra-PAG injection were used in the present study. RESULTS: HRP retrograde tracing results showed that the striatum or accumbens nucleus connect with PAG by two pathways: 1) striatum or accumbens nucleus --> arcuate nucleus --> PAG; 2) striatumor accumbens nucleus --> habenula --> PAG. It was found that neurons in the arcuate nucleus projecting to PAG were mainly beta-endorphin neurons as observed by HRP retrograde tracing combined with immuno-histochemistry. After lesion of the arcuate nucleus, the analgesic action of l-THP (40 mg.kg(-1), ip) was abolished, while lesion of the habenula had no such effect. Moreover, intra-PAG injection of naloxone (2, 3 mu g) could markedly attenuate the analgesic action of E-THP (40 mg kg-l, ip) in a dose-dependent manner. CONCLUSION: beta-Endorphin neurons in the arcuate nucleus play an importantrole in the analgesic action of l-THP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:55:47