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Titolo:
Effect of melatonin on pro-opiomelanocortin mRNA expression in arcuate nucleus of rat hypothalamus
Autore:
Yu, CX; Wu, GC; Xu, SF; Chen, CH;
Indirizzi:
Fujian Med Univ, Dept Pharmacol, Fuzhou 350004, Peoples R China Fujian MedUniv Fuzhou Peoples R China 350004 ou 350004, Peoples R China Shanghai Med Univ, Dept Neurobiol, State Key Lab Med Neurobiol, Shanghai 200032, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200032 00032, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 5, volume: 21, anno: 2000,
pagine: 421 - 424
SICI:
0253-9756(200005)21:5<421:EOMOPM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ENDORPHIN; ANALGESIA; MICE;
Keywords:
melatonin; pro-opiomelanocortin; messenger RNA; arcuate nucleus; in situ hybridization; computer-assisted image processing; analgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Yu, CX Fujian Med Univ, Dept Pharmacol, Fuzhou 350004, Peoples R China Fujian Med Univ Fuzhou Peoples R China 350004 04, Peoples R China
Citazione:
C.X. Yu et al., "Effect of melatonin on pro-opiomelanocortin mRNA expression in arcuate nucleus of rat hypothalamus", ACT PHAR SI, 21(5), 2000, pp. 421-424

Abstract

AIM: To observe altered expression of pro-opiomelanocortin (POMC) mRNA localized in neurons in the arcuate nucleus of rat hypothalamus following exogenous administration of melatonin. METHODS: The experimental animals were divided into two groups injected ip with melatonin 90 mg.kg(-1) and vehicle at 12 h interval (9:00 am and 9:00 pm). Twelve hours after the last injection, the rat brains were processed for coronal sections and nonradioactive in situ hybridization histochemistry technic was used. The integral optical density (IOD) and mean optical density (OD) of the stained brain sections were measured using the computer-assisted image processing technique. RESULTS: The POMC mRNA expression in the arcuate nucleus showed obvious enhancement in the brain sections of rats treated with melatonin. The IOD and OD values in the hypothalamic arcuate nucleus area were increased significantly (P < 0.01, P < 0.05 respectively) with melatonin treatment. CONCLUSION: Melatonin may enhance the POMC mRNA expression in the arcuate nucleus of rat hypothalamus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:38:51