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Titolo:
Sinonasal teratocarcinosarcoma: Ultrastructural and immunohistochemical evidence of neuroectodermal origin
Autore:
Shimazaki, H; Aida, S; Tamai, S; Miyazawa, T; Nakanobou, M;
Indirizzi:
Natl Def Med Coll Hosp, Dept Lab Med, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Hosp Tokorozawa Saitama Japan 3598513 ma 3598513, Japan Natl Def Med Coll Hosp, Dept Neurosurg, Tokorozawa, Saitama 3598513, JapanNatl Def Med Coll Hosp Tokorozawa Saitama Japan 3598513 ma 3598513, Japan Natl Def Med Coll Hosp, Dept Otorhinolaryngol, Tokorozawa, Saitama 3598513, Japan Natl Def Med Coll Hosp Tokorozawa Saitama Japan 3598513 ma 3598513, Japan
Titolo Testata:
ULTRASTRUCTURAL PATHOLOGY
fascicolo: 2, volume: 24, anno: 2000,
pagine: 115 - 122
SICI:
0191-3123(200003/04)24:2<115:STUAIE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARA-NASAL SINUSES; TERATOID CARCINOSARCOMA; PARANASAL;
Keywords:
immunohistochemical study; nasopharyngeal neoplasms; paranasal neoplasms; teratocarcinosarcoma; ultrastructural study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Shimazaki, H Natl Def Med Coll Hosp, Dept Lab Med, 3-2 Namiki, Tokorozawa,Saitama 3598513, Japan Natl Def Med Coll Hosp 3-2 Namiki Tokorozawa Saitama Japan 3598513
Citazione:
H. Shimazaki et al., "Sinonasal teratocarcinosarcoma: Ultrastructural and immunohistochemical evidence of neuroectodermal origin", ULTRA PATH, 24(2), 2000, pp. 115-122

Abstract

The authors report a case of sinonasal teratocarcinosarcoma in a 37-year-old man, which was located in the anterior skull base and extended to the right nasal cavity and paranasal sinuses. The tumor was surgically resected twice, but it could not be removed completely. Microscopically, it was mainly composed of primitive cell nests within a moderately cellular stroma. Thecomponents of squamous cell epithelia with focal teratoid appearance and adenocarcinomatous differentiation were observed. There were many rhabdomyoblasts scattered in the nests and stroma. Ultrastructurally, the primitive cells had many neural processes with parallel microtubules, resembling olfactory neuroblastoma. Rhabdomyoblasts showed various degrees of skeletal muscle differentiation. Some of the stromal spindle cells had actin filaments with dense patches and dense core granules. Immunohistochemically, the primitive cells were positive for epithelial markers, neuron-specific enolase, synaptophysin, and myogenic regulatory proteins. The rhabdomyoblasts showed immunoreactivity for myoid markers, cytokeratin, epithelial membrane antigen, and synaptophysin. Most of the stromal spindle cells were positive for smooth muscle actin, neuron-specific enolase and synaptophysin. The immunohistochemical and ultrastructural findings suggest that primitive cells had the most primitive phenotype of placodes, and support the possibility that sinonasal teratocarcinosarcoma is essentially a neuroectodermal tumor with divergent differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:00:25