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Titolo:
Proteoglycans and pattern formation - Sugar biochemistry meets developmental genetics
Autore:
Selleck, SB;
Indirizzi:
Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA Univ ArizonaTucson AZ USA 85721 ol & Cellular Biol, Tucson, AZ 85721 USA
Titolo Testata:
TRENDS IN GENETICS
fascicolo: 5, volume: 16, anno: 2000,
pagine: 206 - 212
SICI:
0168-9525(200005)16:5<206:PAPF-S>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARAN-SULFATE PROTEOGLYCANS; GOLABI-BEHMEL-SYNDROME; CELL-SURFACE; GROWTH-FACTOR; TUMOR SUPPRESSORS; FIBROBLAST GROWTH; WINGLESS PROTEIN; MAST-CELLS; TOUT-VELU; DROSOPHILA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Selleck, SB Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA Univ Arizona Tucson AZ USA 85721 r Biol, Tucson, AZ 85721 USA
Citazione:
S.B. Selleck, "Proteoglycans and pattern formation - Sugar biochemistry meets developmental genetics", TRENDS GEN, 16(5), 2000, pp. 206-212

Abstract

While it has been long appreciated that sugar-modified proteins coat the cell surface, their functions are poorly understood. Here, I describe recentgenetic studies that demonstrate that one class of sugar-modified proteins, cell-surface proteoglycans, play crucial roles in morphogenesis, growth regulation and tumor suppression. Mutations that affect individual proteoglycans or the enzymes required for glycosaminoglycan synthesis regulate Wingless and Decapentaplegic signaling in Drosophila, and body size in mice and humans. Compromising proteoglycan function is also associated with the development of Wilm's tumors and hereditary multiple exostoses. In this review,these biological findings are placed in the context of proteoglycan biochemistry and molecular function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:40:49