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Titolo:
Carbon monoxide poisoning - a public health perspective
Autore:
Raub, JA; Mathieu-Nolf, M; Hampson, NB; Thom, SR;
Indirizzi:
US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 ssment, Res Triangle Pk, NC 27711 USA Ctr Antipoisons, F-59037 Lille, France Ctr Antipoisons Lille France F-59037 Antipoisons, F-59037 Lille, France Virginia Mason Med Ctr, Pulm & Crit Care Med Sect, Seattle, WA 98111 USA Virginia Mason Med Ctr Seattle WA USA 98111 d Sect, Seattle, WA 98111 USA Univ Penn, Dept Emergency Med, Inst Environm Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 ironm Med, Philadelphia, PA 19104 USA
Titolo Testata:
TOXICOLOGY
fascicolo: 1, volume: 145, anno: 2000,
pagine: 1 - 14
SICI:
0300-483X(20000407)145:1<1:CMP-AP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN LIPID-PEROXIDATION; CEREBRAL BLOOD-FLOW; HYPERBARIC-OXYGEN; NORMOBARIC OXYGEN; EXPOSURE DURATION; VASCULAR INJURY; RAT-BRAIN; INTOXICATION; GLUCOSE; CARBOXYHEMOGLOBIN;
Keywords:
carbon monoxide; carboxyhemoglobin; air pollution; poisoning; indoor; health effects; hyperbaric oxygen;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
117
Recensione:
Indirizzi per estratti:
Indirizzo: Raub, JA US EPA, Natl Ctr Environm Assessment, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Triangle Pk, NC 27711 USA
Citazione:
J.A. Raub et al., "Carbon monoxide poisoning - a public health perspective", TOXICOLOGY, 145(1), 2000, pp. 1-14

Abstract

Carbon monoxide (CO) may be the cause of more than one-half of the fatal poisonings reported in many countries; Fatal cases also are grossly under-reported or misdiagnosed by medical professionals. Therefore, the precise number of individuals who have suffered from CO intoxication is not known. Thehealth effects associated with exposure to CO range from the more subtle cardiovascular and neurobehavioral effects at low concentrations to unconsciousness and death after acute or chronic exposure to higher concentrations of CO. The morbidity and mortality resulting from the latter exposures are described briefly to complete the picture of CO exposure in present-day society. The symptoms, signs, and prognosis of acute CO poisoning correlate poorly with the level of carboxyhemoglobin (COHb) measured at the time of hospital admission. however, because CO poisoning is a diagnosis frequently overlooked, the importance of measuring COHb in suspicious settings cannot beoverstated. The early symptoms (headache, dizziness, weakness, nausea, confusion, disorientation, and visual disturbances) also have to be emphasized, especially if they recur with a regular periodicity or in the same environment. Complications occur frequently in CO poisoning. Immediate death is most likely cardiac in origin because myocardial tissues are most sensitive to the hypoxic effects of CO. Severe poisoning results in marked hypotension. lethal arrhythmias, and electrocardiographic changes. Pulmonary edema may occur. Neurological manifestation of acute CO poisoning includes disorientation, confusion, and coma. Perhaps the most insidious effect of CO poisoning is the development of delayed neuropsychiatric impairment within 2-28 days after poisoning and the slow resolution of neurobehavioral consequences. Carbon monoxide poisoning during pregnancy results in high risk for the mother by increasing the short-term complication rate and for the fetus by causing fetal death, developmental disorders, and chronic cerebral lesions. In conclusion, CO poisoning occurs frequently; has severe consequences, including immediate death; involves complications and late sequelae: and oftenis overlooked. Efforts in prevention and in public and medical education should be encouraged. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:11:31