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Titolo:
Presynaptic dopamine D-4 receptor localization in the rat nucleus accumbens shell
Autore:
Svingos, AL; Periasamy, S; Pickel, VM;
Indirizzi:
Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, New York, NY 10021 USA Cornell Univ New York NY USA 10021 rol & Neurosci, New York, NY 10021 USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 36, anno: 2000,
pagine: 222 - 232
SICI:
0887-4476(20000601)36:3<222:PDDRLI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR GRANULE CELLS; VENTRAL TEGMENTAL AREA; D4 RECEPTORS; EXTRACELLULAR CONCENTRATION; CHOLINE-ACETYLTRANSFERASE; BEHAVIORAL SENSITIZATION; SYNAPTIC ORGANIZATION; D-4-LIKE RECEPTORS; CORPUS STRIATUM; GABA NEURONS;
Keywords:
catecholamine; immunocytochemistry; atypical antipsychotics; psychostimulant; schizophrenia; electron microscopy; neuroleptic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Svingos, AL Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, 411 E69th St, New York, NY 10021 USA Cornell Univ 411 E 69th St New York NY USA 10021 NY 10021 USA
Citazione:
A.L. Svingos et al., "Presynaptic dopamine D-4 receptor localization in the rat nucleus accumbens shell", SYNAPSE, 36(3), 2000, pp. 222-232

Abstract

Dopamine D-4 receptors in the nucleus accumbens shell (AcbSh) are thought to play a key role in mediating the locomotor and sensitizing affects of psychostimulants, as well as the therapeutic efficacy of atypical antipsychotic drugs. We used electron microscopic immunocytochemistry to determine thefunctional sites for endogenous and exogenous D-4 receptor activation in this region. Of 1,090 D-4 receptor-labeled profiles observed in the AcbSh ofrat brain, 65% were axons and axon terminals, while 22% were dendrites anddendritic spines. Within axons and terminals, D-4 receptor immunoreactivity was localized to segments of the plasma membrane and membranes of nearby vesicles. The axon terminals were morphologically heterogenous, varying in size and content of either all small synaptic vesicles (ssv), or ssv and large dense-core vesicles. The labeled terminals occasionally formed asymmetric excitatory-type axospinous synapses, but the majority were without recognizable synaptic specializations. In a separate series of tissue sections that were processed for dual-labeling of the D-4 receptor and the catecholamine synthesizing enzyme, tyrosine hydroxylase (TH), 56% of all observed associations were appositions between differentially labeled axonal profiles, and 17% were terminals that contained immunoreactivity for both antigens. Dendritic spines containing D-4 receptor-labeling also received convergent input from TH-immunoreactive terminals and unlabeled terminals forming asymmetric synapses. These results provide the first ultrastructural evidence for a major presynaptic, and a more minor postsynaptic, involvement of D-4 receptors in dopaminergic modulation of excitatory transmission in the AcbSh. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:55:56