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Titolo:
Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat
Autore:
Gobert, A; Rivet, JM; Lejeune, F; Newman-Tancredi, A; Adhumeau-Auclair, A; Nicolas, JP; Cistarelli, L; Melon, C; Millan, MJ;
Indirizzi:
Inst Rech Servier, Dept Psychopharmacol, F-78290 Crossy Sur Seine, France Inst Rech Servier Crossy Sur Seine France F-78290 ossy Sur Seine, France Inst Rech Servier, Dept Mol & Cellular Pharmacol, F-78290 Crossy Sur Seine, France Inst Rech Servier Crossy Sur Seine France F-78290 ossy Sur Seine, France
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 36, anno: 2000,
pagine: 205 - 221
SICI:
0887-4476(20000601)36:3<205:SRTSTA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREELY-MOVING RATS; MEDIAL PREFRONTAL CORTEX; NEURONS IN-VITRO; LOCUS COERULEUS NEURONS; PARS RETICULATA NEURONS; 5-HT2C RECEPTORS; FRONTAL-CORTEX; NUCLEUS-ACCUMBENS; PHARMACOLOGICAL CHARACTERIZATION;
Keywords:
frontal cortex; ventrotegmental area; locus coeruleus; depression; schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
106
Recensione:
Indirizzi per estratti:
Indirizzo: Gobert, A Inst Rech Servier, Dept Psychopharmacol, 125 Chemin de Ronde, F-78290 Crossy Sur Seine, France Inst Rech Servier 125 Chemin de Ronde CrossySur Seine France F-78290
Citazione:
A. Gobert et al., "Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat", SYNAPSE, 36(3), 2000, pp. 205-221

Abstract

The present study evaluated, via a combined electrophysiological and dialysis approach, the potential influence of serotonin (5-HT)(2C) as compared to 5-HT2A and 5-HT2B receptors on dopaminergic, adrenergic, and serotonergictransmission in frontal cortex (FCX). Whereas the selective 5-HT2A antagonist MDL100,907 failed to modify extracellular levels of dopamine (DA), noradrenaline (NA) or 5-HT simultaneously quantified in single dialysate samples of freely-moving rats, the 5-HT2B/5-HT2C antagonist SB206,553 dose-dependently increased levels of DA and NA without affecting those of 5-HT. This action was attributable to 5-HT2C receptor blockade inasmuch as the selective 5-HT2C antagonist SB242,084 likewise increased FCX levels of DA and NA, whereas the selective 5-HT2B antagonist SB204,741 was ineffective. Further, the preferential 5-HT2C receptor agonist Ro60-0175 dose-dependently depressed FCX levels of DA. The suppressive influence of 5-HT2B receptors on DA release was also expressed on mesolimbic and nigrostriatal dopaminergic pathways, in that levels of DA in nucleus accumbens and striatum were likewise reduced by Ro60-0175 and elevated, though less markedly, by SB206,553. In Line with the above findings, Ro60-0175 dose-dependently decreased the firingrate of ventrotegmental dopaminergic and locus coeruleus (LC) adrenergic perikarya, whereas their activity was dose-dependently enhanced by SB206,553. Furthermore, SB206,553 transformed the firing pattern of ventrotegmental dopaminergic neurons into a burst mode. In contrast to SB206,553, MDL100,907 had little affect on the firing rate of dopaminergic or adrenergic neurons. In conclusion, as compared to 5-HT2A and 5-HT2B receptors, 5-HT2C receptors exert a tonic, suppressive influence on the activity of mesocortical - as well as mesolimbic and nigrostriatal dopaminergic pathways, likely via indirect actions expressed at the level of their cell bodies. Frontocorticaladrenergic, but not serotonergic, transmission is also tonically suppressed by 5-HT2C receptors. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:37:20