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Titolo:
beta-adrenergic receptors primarily are located on the dendrites of granule cells and interneurons but also are found on astrocytes and a few presynaptic profiles in the rat dentate gyrus
Autore:
Milner, TA; Shah, P; Pierce, JP;
Indirizzi:
Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, Div Neurobiol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Div Neurobiol, New York, NY 10021 USA
Titolo Testata:
SYNAPSE
fascicolo: 3, volume: 36, anno: 2000,
pagine: 178 - 193
SICI:
0887-4476(20000601)36:3<178:BRPALO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL-FORMATION; ULTRASTRUCTURAL-LOCALIZATION; INTRACEREBROVENTRICULAR NOREPINEPHRINE; ELECTROPHYSIOLOGICAL CHARACTERIZATION; IMMUNOCYTOCHEMICAL LOCALIZATION; ALPHA(2A)-ADRENERGIC RECEPTORS; CATECHOLAMINERGIC TERMINALS; BETA-2-ADRENERGIC RECEPTORS; SPECIES-DIFFERENCES; ALPHA-ADRENOCEPTOR;
Keywords:
catecholamine receptors; postsynaptic densities; parvalbumin; volume transmission; electron microscopy; hippocampal formation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Milner, TA Cornell Univ, Weill Med Coll, Dept Neurol & Neurosci, Div Neurobiol, 411 E69th St, New York, NY 10021 USA Cornell Univ 411 E 69th St New York NY USA 10021 , NY 10021 USA
Citazione:
T.A. Milner et al., "beta-adrenergic receptors primarily are located on the dendrites of granule cells and interneurons but also are found on astrocytes and a few presynaptic profiles in the rat dentate gyrus", SYNAPSE, 36(3), 2000, pp. 178-193

Abstract

In the rat dentate gyrus, beta-adrenergic receptor (beta-AR) activation isthought to be important in mediating the effects of norepinephrine (NE). beta-AR-immunoreactivity (beta-AR-I) was localized in this study by light and electron microscopy in the rat dentate gyrus by using two previously characterized antibodies to the beta-AR. By light microscopy, dense beta-AR-I was observed in the somata of granule cells and a few hilar interneurons. Diffuse and slightly granular beta-AR-I was found in all laminae, although itwas most noticeable in the molecular layer. Ultrastructurally, the cytoplasm of granule cell and interneuronal perikarya (some of which contained parvalbumin immunoreactivity) contained beta-AR-I. beta-AR-I was associated primarily with the endoplasmic reticula; however, a few patches were observednear the plasmalemma. Quantitative analysis revealed that the greatest proportion of beta-AR-labeled profiles was found in the molecular layer. The majority of beta-AR-labeled profiles were either dendritic or astrocytic. Indendritic profiles, beta-AR-I was prominent near postsynaptic densities inlarge dendrites, many of which originated from granule cell somata. Moreover, some beta-AR-I was found in dendritic spines, sometimes affiliated withthe spine apparati. Astrocytic profiles with beta-AR-I were commonly foundnext to unlabeled terminals which formed asymmetric (excitatory-type) synapses with dendritic spines. Additionally, beta-AR-I was observed in a few unmyelinated axons and axon terminals, many of which formed synapses with dendritic spines. Dual-labeling studies revealed that axone and axon terminals containing tyrosine hydroxylase (TH), the catecholamine synthesizing enzyme, often were near both neuronal and glial profiles containing beta-AR-I. These studies demonstrate that hippocampal beta-AR-I is localized: 1) principally in postsynaptic sites on granule cells and a few interneurons (some of which were basket cells); and 2) in glial processes. These observations add further support to the contention that beta-AR-activation modulates synaptic function through disparate pathways: directly, at either postsynapticdensities or presynaptic processes, or indirectly, through adjacent glial processes. (C) 2000 Wiley-Liss, Inc.

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Documento generato il 05/04/20 alle ore 03:45:39