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Titolo:
Dopamine D-2 receptor quantification in extrastriatal brain regions using [I-123]epidepride with bolus/infusion
Autore:
Pinborg, LH; Videbaek, C; Knudsen, GM; Swahn, CG; Halldin, C; Friberg, L; Paulson, OB; Lassen, NA;
Indirizzi:
Univ Copenhagen Hosp, Rigshosp, Neurobiol Res Unit, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Karolinska Inst, Karolinska Hosp, Psychiat Sect, Dept Clin Neurosci, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 osci, S-10401 Stockholm, Sweden Bispebjerg Hosp, Dept Nucl Med, DK-2400 Copenhagen, Denmark Bispebjerg Hosp Copenhagen Denmark DK-2400 , DK-2400 Copenhagen, Denmark
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 36, anno: 2000,
pagine: 322 - 329
SICI:
0887-4476(20000615)36:4<322:DDRQIE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVING HUMAN-BRAIN; POSITRON EMISSION TOMOGRAPHY; GRAPHICAL ANALYSIS; I-125 EPIDEPRIDE; BINDING; INFUSION; PET; QUANTITATION; BOLUS;
Keywords:
epidepride; extrastriatal dopamine D-2 receptor; quantification; SPECT; infusion; steady state; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Pinborg, LH Univ Copenhagen Hosp, Rigshosp, Neurobiol Res Unit, N9201,9 Blegdamsvej, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp N9201,9 Blegdamsvej Copenhagen Denmark DK-2100
Citazione:
L.H. Pinborg et al., "Dopamine D-2 receptor quantification in extrastriatal brain regions using [I-123]epidepride with bolus/infusion", SYNAPSE, 36(4), 2000, pp. 322-329

Abstract

The iodinated benzamide epidepride, which shows a picomolar affinity binding to dopamine D-2 receptors, has been designed for in vivo studies using SPECT. The aim of the present study was to apply a steady-state condition bythe bolus/infusion approach with [I-123]epidepride for the quantification of striatal and extrastriatal dopamine D-2 receptors in humans. In this waythe distribution volume of the tracer can be determined from a single SPECT image and one blood sample. Based on bolus experiments, an algorithm using conventional convolution arguments for prediction of the outcome of a bolus/infusion (B/I) experiment was applied. It was predicted that a B/I protocol with infusion of one-third of the initial bolus per hour would be appropriate. Steady-state conditions were attained in extrastriatal regions within 3-4 h but the infusion continued up to 7 h in order to minimize the significance of individual differences in plasma clearance and binding parameters. A steady-state condition, however, could not be attained in striatal brain regions using a B/I protocol of 20 h, even after 11 h. Under near steady-state conditions a striatal:cerebellar ratio of 23 was demonstrated. Epidepride has a unique signal-to-noise ratio compared to [I-123]IBZM but present difficulties for steady-state measurements of striatal regions. The bolus/infusion approach is particularly feasible for quantification of the binding potential in extrastriatal regions. Synapse 36:322-329, 2000, (C) 2000 Wiley-Liss, Inc.

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Documento generato il 20/11/19 alle ore 02:28:02