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Titolo:
Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin ordopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulate, and the dorsal raphe nucleus slices
Autore:
Iravani, MM; Asari, D; Patel, J; Wieczorek, WJ; Kruk, ZL;
Indirizzi:
Univ London Queen Mary & Westfield Coll, Dept Pharmacol, London E1 4NS, England Univ London Queen Mary & Westfield Coll London England E1 4NS S, England
Titolo Testata:
SYNAPSE
fascicolo: 4, volume: 36, anno: 2000,
pagine: 275 - 285
SICI:
0887-4476(20000615)36:4<275:DEO3(O>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN SLICES; CARRIER-MEDIATED RELEASE; FAST CYCLIC VOLTAMMETRY; 5-HYDROXYTRYPTAMINE RELEASE; METHYLENEDIOXYMETHAMPHETAMINE MDMA; SUBSTITUTED AMPHETAMINES; REVERSE TRANSPORT; MICE LACKING; REAL-TIME; NEURONS;
Keywords:
MDMA (ecstasy); dopamine; serotonin; uptake; fast cyclic voltammetry; caudate putamen; dorsal raphe nucleus; nucleus accumbens; substantia nigra pars reticulata;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Iravani, MM Guys Kings & St Thomas Sch Biomed Sci, Div Pharmacol & Therapeut, Neurodegenerat Dis Res Ctr, Guys Campus,Hodgkin Bldg, London SE1 1UL, England Guys Kings & St Thomas Sch Biomed Sci Guys Campus,Hodgkin Bldg London England SE1 1UL
Citazione:
M.M. Iravani et al., "Direct effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin ordopamine release and uptake in the caudate putamen, nucleus accumbens, substantia nigra pars reticulate, and the dorsal raphe nucleus slices", SYNAPSE, 36(4), 2000, pp. 275-285

Abstract

We examined the effects of pressure ejected 3,4-methylenedioxymethamphetamine (MDMA) from a micropipette on direct chemically stimulated release, andon electrically stimulated serotonin (5-HT) or dopamine (DA) release in the caudate putamen (CPu), nucleus accumbens (NAc), substantia nigra pars reticulata (SNr), and the dorsal raphe nucleus (DRN) brain slices of rat, using fast cyclic voltammetry (FCV). MDMA is electroactive, oxidising at +1100 mV. When the anodic input waveform was reduced from +1.4 to +1.0 volt, MDMAwas not electroactive. Using this waveform, pressure ejection of MDMA did not release 5-HT or DA in brain slices prepared from any of the nuclei studied. MDMA significantly potentiated electrically stimulated 5-HT release inthe SNr and DA release in CPu. In the DRN or in the NAc, MDMA was without effect on peak electrically stimulated 5-HT or DA release. The rates of neurotransmitter uptake, expressed as t(1/2), were in all cases significantly decreased after MDMA. The results indicate that MDMA, unlike (+)amphetamine, is not as a releaser of DA or 5-HT, it is a potent inhibitor of both DA and 5-HT uptake. Synapse 36: 275-285, 2000, (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:51:23