Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Familial adenomatous polyposis
Autore:
Lal, G; Gallinger, S;
Indirizzi:
Univ Toronto, Dept Surg, Div Gen Surg, Toronto, ON, Canada Univ Toronto Toronto ON Canada t Surg, Div Gen Surg, Toronto, ON, Canada
Titolo Testata:
SEMINARS IN SURGICAL ONCOLOGY
fascicolo: 4, volume: 18, anno: 2000,
pagine: 314 - 323
SICI:
8756-0437(200006)18:4<314:FAP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL-PIGMENT EPITHELIUM; POUCH-ANAL ANASTOMOSIS; DESMOID TUMORS; APC GENE; COLORECTAL-CANCER; CONGENITAL HYPERTROPHY; SCREENING GUIDELINES; THYROID-CARCINOMA; COLI GENE; MUTATIONS;
Keywords:
adenomatous polyposis coil; genetics/diagnosis/pathology/surgery; colorectal neoplasms; intestinal polyps; incidence; APC genes; hypertrophy/congenital pigment epithelium of eye; Gardner syndrome; epidermal cyst; osteoma; aggressive fibromatosis; brain neoplasms/genetics; linkage (genetics); mutation; mice; heterozygote detection; colectomy; restorative proctocolectomy; ileostomy; non-steroidal anti-inflammatory agents; sulindac; cyclooxygenase inhibitors; postoperative complications; genetic screening; genetic counseling; endoscopy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Gallinger, S Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Ctr Canc Genet, 600Univ Ave,Suite 1225, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave,Suite 1225 Toronto ON Canada M5G 1X5
Citazione:
G. Lal e S. Gallinger, "Familial adenomatous polyposis", SEM SURG ON, 18(4), 2000, pp. 314-323

Abstract

Familial adenomatous polyposis (FAP) is a dominantly inherited familial cancer syndrome characterized by an increased predisposition to colorectal cancer and other benign and malignant extracolonic lesions. FAP has been linked to germline mutations of the adenomatous polyposis coli (APC) gene that encodes a protein with 2,843 amino acids that has important functions in the regulation of cell growth. A genotype-phenotype correlation has also beenobserved between mutations in the APC gene and polyp phenotype. We review the clinical and genetic features of this disorder and provide information on the diagnostic approaches and treatment options available for this disease. Semin. Surg. Oncol. 18:314-323. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 16:10:39