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Titolo:
Muir-Torre-like syndrome in Fhit-deficient mice
Autore:
Fong, LYY; Fidanza, V; Zanesi, N; Lock, LF; Siracusa, LD; Mancini, R; Siprashvili, Z; Ottey, M; Martin, SE; Druck, T; McCue, PA; Croce, CM; Huebner, K;
Indirizzi:
Thomas Jefferson Univ, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Thomas Jefferson Univ, Kimmel Canc Ctr, Christiana Care Hlth Syst, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 9, volume: 97, anno: 2000,
pagine: 4742 - 4747
SICI:
0027-8424(20000425)97:9<4742:MSIFM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; N-NITROSOMETHYLBENZYLAMINE; CELL-PROLIFERATION; ZINC-DEFICIENCY; TUMOR-CELLS; LUNG-CANCER; GENE; EXPRESSION; ESOPHAGEAL; CARCINOMAS;
Keywords:
esophageal/gastric cancer; N-nitrosomethylbenzylamine; carcinogen-induced tumorigenesis; Fhit knockout mice; tumor suppressor gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Huebner, K Thomas Jefferson Univ, Dept Microbiol & Immunol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 , PA 19107 USA
Citazione:
L.Y.Y. Fong et al., "Muir-Torre-like syndrome in Fhit-deficient mice", P NAS US, 97(9), 2000, pp. 4742-4747

Abstract

To investigate the role of the Fhit gene in carcinogen induction of neoplasia, we have inactivated one Fhit allele in mouse embryonic stem cells and produced (129/SvJ x C57BL/6J) F-1 mice with a Fhit allele inactivated (+/-). Fhit +/+ and +/- mice were treated intragastrically with nitrosomethylbenzylamine and observed for 10 wk posttreatment. A total of 25% of the +/+ mice developed adenoma or papilloma of the forestomach, whereas 100% of the +/- mice developed multiple tumors that were a mixture of adenomas, squamouspapillomas, invasive carcinomas of the forestomach, as well as tumors of sebaceous glands. The visceral and sebaceous tumors, which lacked Fhit protein, were similar to those characteristic of Muir-Torre familial cancer syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:13:57