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Titolo:
Oxyntomodulin inhibits pancreatic secretion through the nervous system in rats
Autore:
Anini, Y; Jarrousse, C; Chariot, J; Nagain, C; Yanaihara, N; Sasaki, K; Bernad, N; Nguyen, DL; Bataille, D; Roze, C;
Indirizzi:
Fac Med Xavier Bichat, INSERM, U410, F-75870 Paris 18, France Fac Med Xavier Bichat Paris France 18 RM, U410, F-75870 Paris 18, France CHU Arnaud Villeneuve, INSERM, U376, Montpellier, France CHU Arnaud Villeneuve Montpellier France ERM, U376, Montpellier, France Fac Pharm Montpellier, CNRS, UMR 5810, F-34060 Montpellier, France Fac Pharm Montpellier Montpellier France F-34060 060 Montpellier, France Yanaihara Inst Inc, Shizuoka, Japan Yanaihara Inst Inc Shizuoka JapanYanaihara Inst Inc, Shizuoka, Japan Nisshin Flour Milling Co Ltd, Tokyo, Japan Nisshin Flour Milling Co Ltd Tokyo Japan r Milling Co Ltd, Tokyo, Japan
Titolo Testata:
PANCREAS
fascicolo: 4, volume: 20, anno: 2000,
pagine: 348 - 360
SICI:
0885-3177(200005)20:4<348:OIPSTT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; PEPTIDE-YY; ENZYME SECRETION; SMALL-INTESTINE; NEUROPEPTIDE-Y; CONSCIOUS RAT; EXOCRINE; GLUCAGON; CHOLECYSTOKININ; PANCREASTATIN;
Keywords:
oxyntomodulin; oxyntomodulin 19-37; glicentin; peptide YY; GLP-1; pancreatic secretion; cholecystokinin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Roze, C Fac Med Xavier Bichat, INSERM, U410, BP 416, F-75870 Paris 18, France Fac Med Xavier Bichat BP 416 Paris France 18 870 Paris 18, France
Citazione:
Y. Anini et al., "Oxyntomodulin inhibits pancreatic secretion through the nervous system in rats", PANCREAS, 20(4), 2000, pp. 348-360

Abstract

Glicentin (GLIC), oxyntomodulin (OXM), and peptide YY (PYY) released in blood by ileocolonic L-cells after meals may inhibit pancreatic secretion. Whereas OXM interacts with glucagon and tCLP-1 receptors, OXM 19-37, a biologically active fragment, does not. The purpose of this study was to measure the effect of OXM, OXM 19-37, GLIC, tGLP-1, and PYY on pancreatic secretionstimulated by 2 deoxyglucose (2DG), electrical stimulation of the vagus nerves (VES), acetylcholine and cholecystokinin octapeptide (CCK8) in anesthetized rats. The effect of OXM was also studied in dispersed pancreatic acini. Plasma oxyntomodulin-like immunoreactivity (OLI) was measured by radioimmunoassay after the exogenous infusion of OXM and after an intraduodenal meal. OXM 19-37, infused at doses mimicking postprandial plasma levels of OLI, decreased pancreatic secretion stimulated by 2DG, VES, or CCK8. Similar effects were found with OXM and GLIC. OXM 19-37 did not change the pancreatic stimulation induced by acetylcholine in vivo, or CCK-induced amylase release in isolated acini. Vagotomy completely suppressed the inhibitory effectof OXM 19-37 on CCK8-stimulated pancreatic secretion. PW inhibited the effect of 2DG, but not that of CCK8, whereas tGLP-1, even in pharmacologic doses, had no effect on stimulated pancreatic secretion. OXM, OXM 19-37, but not tGLP-1, inhibit pancreatic secretion at physiologic doses, through a vagal neural indirect mechanism, different from that used by PYY, and probablythrough a GLIC-related peptide-specific receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 01:01:49