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Titolo:
Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition
Autore:
Dulawa, SC; Gross, C; Stark, KL; Hen, R; Geyer, MA;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ New York NY USA 10032 obiol & Behav, New York, NY 10032 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 6, volume: 22, anno: 2000,
pagine: 650 - 659
SICI:
0893-133X(200006)22:6<650:KMRORF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; 5-HT1B RECEPTOR; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; SCHIZOPHRENIC-PATIENTS; VENTRAL PALLIDUM; TACTILE STARTLE; BINDING-SITES; HUMAN-BRAIN; RAT-BRAIN; HABITUATION;
Keywords:
sensorimotor gating; startle habituation; anpirtoline; 8-OH-DPAT; flesinoxan; RU 24969;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Geyer, MA Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 93 USA
Citazione:
S.C. Dulawa et al., "Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition", NEUROPSYCH, 22(6), 2000, pp. 650-659

Abstract

The serotonergic system is involved in the modulation of prepulse inhibition (PPI) and habituation of startle, which are deficient in schizophrenia patients. PPI is the reduction in startle amplitude that occurs when a weak "prepulse" precedes a startling stimulus by 30-500 msec. The roles of 5-HT1A and 5-HT1B receptors in modulating PPI and habituation were examined using wild-type (WT), 5-HT1A knockout (1AKO), and 5-HT1B knockout (1BKO) mice. The 5-HT1A/1B agonist RU24969 reduced PPI and habituation in WT and 1AKO, but not 1BKO mice, whereas the 5-HT1A agonist 8-OH-DPAT increased PPI in WT and 1BKO, but not in 1AKO mice. Similarly, the selective 5-HT1B agonist anpirtoline reduced PPI in WT, but not in 1BKO mice. In experiments using intact 129Sv mice, the 5-HT1A agonist flesinoxan increased PPI while anpirtoline decreased PPI and habituation. Findings suggest that 5-HT1B receptor activation decreases PPI and habituation, and 5-HT1A receptor activation increases PPI in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 22:48:16