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Titolo:
Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP
Autore:
Lu, YM; Mansuy, IM; Kandel, ER; Roder, J;
Indirizzi:
Columbia Univ Coll Phys & Surg, Ctr Neurobiol & Behav, Howard Hughes Med Inst, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA10032 w York, NY 10032 USA Univ Toronto, Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Dept Mol & Med Genet, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 Genet, Toronto, ON M5S 1A8, Canada
Titolo Testata:
NEURON
fascicolo: 1, volume: 26, anno: 2000,
pagine: 197 - 205
SICI:
0896-6273(200004)26:1<197:CLOGIU>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RABBIT FOLLOWING STIMULATION; EPSP SPIKE DISSOCIATION; RAT HIPPOCAMPAL SLICES; E-S COMPONENT; SYNAPTIC TRANSMISSION; LASTING POTENTIATION; PERFORANT PATH; POSTSYNAPTIC CALCIUM; DENTATE GYRUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kandel, ER Columbia Univ Coll Phys & Surg, Ctr Neurobiol & Behav, Howard Hughes Med Inst, 722 W 168th St, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 722 W 168th St New York NY USA 10032
Citazione:
Y.M. Lu et al., "Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP", NEURON, 26(1), 2000, pp. 197-205

Abstract

Coincident pre- and postsynaptic activity generates long-term potentiation(LTP), a possible cellular model of learning and memory. LTP has two components: (1) an increase in the excitatory postsynaptic potential (EPSP), and(2) an increase in the ability of the EPSP to generate a spike (ES coupling of LTP). We have used pharmacological and genetic approaches to address the molecular nature of E-S coupling in CA1 pyramidal neurons. Blockade of the Ca2+-sensitive phosphatase, calcineurin, prevents induction of ES coupling without interfering with LTP of the EPSP. Calcineurin produces its effect on E-S coupling by inducing a long-lasting depression (LTD) of the GABA,mediated inhibitory postsynaptic potentials (IPSPs). This LTD of the IPSP was prevented by blockade of NMDA receptors. Thus, the tetanus that elicits NMDA-dependent LTP mediates a coordinately regulated double function. It produces LTP of the EPSP and, concomitantly, LTD of the IPSP that leads to enhancement of E-S coupling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 23:23:07