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Titolo:
The guanine nucleotide exchange factor trio mediates axonal development inthe Drosophila embryo
Autore:
Bateman, J; Shu, H; Van Vactor, D;
Indirizzi:
Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ed, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 , Program Neurosci, Boston, MA 02115 USA Univ Calif Los Angeles, Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USAUniv Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
NEURON
fascicolo: 1, volume: 26, anno: 2000,
pagine: 93 - 106
SICI:
0896-6273(200004)26:1<93:TGNEFT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMEMBRANE TYROSINE PHOSPHATASE; GROWTH CONE GUIDANCE; ACTIN STRESS FIBERS; CELL-SHAPE CHANGES; BINDING PROTEIN; CAENORHABDITIS-ELEGANS; SIGNALING PATHWAY; FACTOR DOMAINS; C-ELEGANS; MOTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Van Vactor, D Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Biol, Boston, MA 02115 USA
Citazione:
J. Bateman et al., "The guanine nucleotide exchange factor trio mediates axonal development inthe Drosophila embryo", NEURON, 26(1), 2000, pp. 93-106

Abstract

Recent analysis of Rho subfamily GTPases in Drosophila revealed roles for Rac and Cdc42 during axonogenesis. Here, we describe the identification andcharacterization of the Drosophila counterpart of Trio, a guanine nucleotide exchange factor (GEF) that associates with the receptor phosphatase LAR and regulates GTPase activation in vertebrate cells. Mutants deficient in trio activity display defects in both central and peripheral axon pathways reminiscent of phenotypes observed in embryos deficient in small GTPase function. Double mutant analysis shows that trio interacts with Rac in a dose-sensitive manner but not with Rho. Moreover, reduction of trio activity potentiates the phenotype of mutations in the LAR homolog Dlar, suggesting thatthese proteins collaborate in orchestrating the cytoskeletal events that underlie normal axonogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:06:32