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Titolo:
Immunoneutralization of endogenous opioid peptides prevents the suckling-induced prolactin increase and the inhibition of tuberoinfundibular dopaminergic neurons
Autore:
Callahan, P; Klosterman, S; Prunty, D; Tompkins, J; Janik, J;
Indirizzi:
Miami Univ, Ctr Neurosci, Dept Zool, Oxford, OH 45056 USA Miami Univ Oxford OH USA 45056 Neurosci, Dept Zool, Oxford, OH 45056 USA
Titolo Testata:
NEUROENDOCRINOLOGY
fascicolo: 4, volume: 71, anno: 2000,
pagine: 268 - 276
SICI:
0028-3835(200004)71:4<268:IOEOPP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; POSTERIOR PITUITARY; BETA-ENDORPHIN; PLASMA PROLACTIN; LACTATING RATS; FEMALE RATS; INTERMEDIATE LOBE; RECEPTOR SUBTYPE; GENE-EXPRESSION; NEURAL ACTIVITY;
Keywords:
dynorphin; opioid peptides; suckling; prolactin; catecholamines; tuberoinfundibular dopamine neurons; arcuate nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Janik, J Miami Univ, Ctr Neurosci, Dept Zool, Oxford, OH 45056 USA Miami Univ Oxford OH USA 45056 , Dept Zool, Oxford, OH 45056 USA
Citazione:
P. Callahan et al., "Immunoneutralization of endogenous opioid peptides prevents the suckling-induced prolactin increase and the inhibition of tuberoinfundibular dopaminergic neurons", NEUROENDOCR, 71(4), 2000, pp. 268-276

Abstract

Previous studies have shown that the endogenous opioid peptides, acting atspecific opiate receptor subtypes, are involved in the suckling-induced prolactin secretory response. The prolactin increase elicited by suckling is due, at least in part, to an inhibition of tuberoinfundibular dopaminergic (TIDA) neurons in the hypothalamus, We investigated the effects of immunoneutralization of dynorphin, leu-enkephalin and met-enkephalin on the suckling-induced prolactin increase and on the activity of the TIDA neurons in lactating female rats between days 7 and 12 postpartum. Rats were injected into the right lateral ventricle with antiserum specific for one of these three peptides, Control rats were administered equal amounts of immunoglobulin proteins. Suckling produced a profound and significant increase in prolactin levels, as well as a decrease in DOPA accumulation in the median eminenceof lactating rats. Administration of immunoglobulin concentrations of up to 3.6 mu g did not inhibit the prolactin secretory response to the sucklingstimulus and did not prevent the suckling-induced inhibition of TIDA neurons. Antisera to all three endogenous opioid peptides abolished the suckling-induced prolactin increase and prevented the inhibition in DOPA accumulation in the median eminence. Thus, the endogenous opioid peptides, dynorphin,leu-enkephalin and metenkephalin, are essential for the prolactin secretory response to suckling and inhibition of TIDA neuronal activity is at leastone of the mechanisms of action utilized by these peptides. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:36:35