Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Exercise shifts the platelet aggregation modulatory role from native to mildly oxidized low-density lipoprotein
Autore:
Hsu, HC; Lee, YT; Chen, MF;
Indirizzi:
Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, Taipei 100, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 100 Med Cardiol, Taipei 100, Taiwan
Titolo Testata:
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
fascicolo: 5, volume: 32, anno: 2000,
pagine: 933 - 939
SICI:
0195-9131(200005)32:5<933:ESTPAM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE MODIFICATION; BETA-THROMBOGLOBULIN; LIPID-PEROXIDATION; PHYSICAL EXERCISE; THROMBOXANE B-2; WHOLE-BLOOD; ACTIVATION; LDL; SERUM; DISEASE;
Keywords:
lipoprotein; blood platelet;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, MF Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, 7 Chung Shan S Rd, Taipei 100, Taiwan Natl Taiwan Univ Hosp 7 Chung Shan S Rd Taipei Taiwan 100 Taiwan
Citazione:
H.C. Hsu et al., "Exercise shifts the platelet aggregation modulatory role from native to mildly oxidized low-density lipoprotein", MED SCI SPT, 32(5), 2000, pp. 933-939

Abstract

Purpose: The role of low-density lipoprotein (LDL) lipid peroxides in strenuous exercise-induced changes in platelet function was studied in 30 patients (male/female = 22/8) aged 30-62 yr (mean +/- SD = 508). Methods: All subjects were subjected to a Treadmill exercise test, using the standard Brace protocol. Blood samples were collected pre-, peak, and 10 min postexercise to assess hematological and biochemical parameters and platelet aggregation. Ex vivo whole blood platelet aggregation during treadmill exercise was assessed in 10 subjects by adding mildly oxidized LDL. Results: Preexercise, a correlation existed between plasma thromboxane (TX) levels and plasma LDL cholesterol or beta-thromboglobulin (P-TG) levels (r = 0.48, P < 0.05; r= 0.47, P < 0.05, respectively), whereas, at peak exercise, TX and beta-TGlevels increased, but no correlation was seen. At peak exercise, plateletsshowed hyperaggregability in terms of maximal amplitude and reaction slope(P < 0.001 and P < 0.01, respectively). In contrast to the increase in plasma lipid peroxide levels seen during peak exercise (P < 0.05), LDL lipid peroxides decreased during exercise, this decrease reaching a statistical significance at 10 min postexercise (P < 0.05). In addition, the ex vivo addition of mildly oxidized LDL (10 mg protein.L-1) to peak exercise blood resulted in a significant attenuation of platelet aggregation and a decrease inTX release. At 10 min postexercise, a correlation was seen between LDL lipid peroxides and TX levels (r = 0.78, P < 0.001) or beta-TG levels (r = 0.68, P < 0.005). Conclusion: These results suggest that LDL lipid peroxides play a role in modulating and attenuating platelet aggregation during strenuous exercise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:09:53