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Titolo:
Plasma epinephrine levels in hypertension and across gender and ethnicity
Autore:
Gonzalez-Trapaga, JL; Nelesen, RA; Dimsdale, JE; Mills, PJ; Kennedy, B; Parmer, RJ; Ziegler, MG;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 24, volume: 66, anno: 2000,
pagine: 2383 - 2392
SICI:
0024-3205(20000505)66:24<2383:PELIHA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NERVOUS-SYSTEM; CARDIOVASCULAR PRESSOR RESPONSIVENESS; SEX-DIFFERENCES; BLOOD-PRESSURE; RACIAL-DIFFERENCES; BORDERLINE HYPERTENSION; CATECHOLAMINE EXCRETION; BEHAVIORAL CHALLENGE; ISOMETRIC-EXERCISE; MENSTRUAL-CYCLE;
Keywords:
catecholamine; normotension; race; norepinephrine; gender; epinephrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Dimsdale, JE Univ Calif San Diego, Dept Psychiat, Mail Code 0804, La Jolla, CA 92093 USA Univ Calif San Diego Mail Code 0804 La Jolla CA USA 92093 USA
Citazione:
J.L. Gonzalez-Trapaga et al., "Plasma epinephrine levels in hypertension and across gender and ethnicity", LIFE SCI, 66(24), 2000, pp. 2383-2392

Abstract

Epinephrine (E) infusions raise blood pressure and there is an excess incidence of hypertension among males and blacks. However, reports off levels by ethnicity, gender, and blood pressure status are inconsistent. Insensitive assays, variability in plasma E levels within individuals, and the small size of most studies have contributed to these conflicting reports. We measured plasma E levels in a large diverse sample of subjects, using a highly sensitive assay. A total of 361 individuals participated in the study: 61% were men and 39% women, 74% were normotensive and 26% hypertensive, 59% were white and 41% were black. Except for difference in blood pressure and body mass index, between the normotensives and hypertensives, subjects had similar baseline characteristics and took no antihypertensive medications for at least five days prior to sampling. All blood samples were collected after resting for a least 30 minutes following the insertion of an indwelling IV catheter. Catecholamine levels were determined using a radioenzymatic assay (assay sensitivities for E and norepinephrine were 6 pg/ml and 10pg/ml, respectively). An ethnicity by gender interaction was found (F-1,F-315 = 5.126, p =.024). Subsequent analysis revealed that white women had significantly lower basal plasma E levels than white men (p <0.001) and black women (p = 0.036). There were no significant differences in E levels between blackmen and women or between white men and black men. Uncorrected E levels were lower in normotensive than hypertensive subjects (p = .009) but this difference was not significant when corrected for body mass index (BMI). Uncorrected norepinephrine levels were higher in women than men (p = .03) but thedifference was no longer significant when corrected for BMI. Plasma E levels were significantly lower among white women than men or black women. In contrast to prior studies, E levels were lower in hypertensives, but this may reflect obesity among hypertensives.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 22:42:17