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Titolo:
Defective megakaryocytic development in myelodysplastic syndromes
Autore:
Hofmann, WK; Kalina, U; Koschmieder, S; Seipelt, G; Hoelzer, D; Ottmann, OG;
Indirizzi:
Johann Wolfgang Goethe Univ Hosp, Dept Haematol, D-60596 Frankfurt, Germany Johann Wolfgang Goethe Univ Hosp Frankfurt Germany D-60596 furt, Germany
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 1-2, volume: 38, anno: 2000,
pagine: 13 - 19
SICI:
1042-8194(200006)38:1-2<13:DMDIMS>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-MPL LIGAND; HUMAN BLOOD-PLATELETS; BONE-MARROW; PROGENITOR CELLS; IN-VITRO; TYROSINE PHOSPHORYLATION; THROMBOPOIETIN RECEPTOR; COLONY FORMATION; GROWTH; EXPRESSION;
Keywords:
megakaryocytes; MDS; myelodysplastic syndrome; c-mpl receptor; thrombopoietin; TPO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Hofmann, WK Univ Calif Los Angeles, Cedars Sinai Med Ctr, Sch Med, Div Hematol & Oncol, Davis Bldg,Room 5005,8700 Beverly Blvd, Los Angeles, CA 90048USA Univ Calif Los Angeles Davis Bldg,Room 5005,8700 Beverly Blvd Los Angeles CA USA 90048
Citazione:
W.K. Hofmann et al., "Defective megakaryocytic development in myelodysplastic syndromes", LEUK LYMPH, 38(1-2), 2000, pp. 13-19

Abstract

Megakaryocytic proliferation and differentiation is typically abnormal in patients with myelodysplastic syndromes (MDS). The underlying mechanisms for this finding are not known, but may involve defects at the level of the thrombopoietin-receptor (c-mpl) or post-receptor signaling pathways in megakaryocyte progenitor cells. Premature apoptosis of the bone marrow cells andinhibitory effects of cytokines such as tumor necrosis factor alpha have been implicated as contributing to altered megakaryopoiesis in MDS, but their significance remains unclear. The availability of thrombopoietin (TPO) has facilitated more detailed analysis of megakaryocytic biology using several experimental in-vitro systems. However numerous studies have shown that the developmental abnormalities of MDS megakaryocytes could not be correctedby TPO, Increasing investigations are being extended to the evaluation of signal transduction pathways of c-mpl both in cell lines and human hematopoietic cells in order to identify the molecular mechanisms responsible for the defective megakaryocytic development in MDS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:35:28