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Titolo:
Attenuated coronary flow reserve and vascular remodeling in patients with hypertension and left ventricular hypertrophy
Autore:
Hamasaki, S; Al Suwaidi, J; Higano, ST; Miyauchi, K; Holmes, DR; Lerman, A;
Indirizzi:
Mayo Clin & Mayo Fdn, Ctr Coronary Physiol & Imaging, Div Cardiovasc Dis, Dept Internal Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 6, volume: 35, anno: 2000,
pagine: 1654 - 1660
SICI:
0735-1097(200005)35:6<1654:ACFRAV>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-SECTIONAL AREA; BLOOD-FLOW; NITRIC-OXIDE; INTRACORONARY ULTRASOUND; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL PERFUSION; VASOMOTOR RESPONSES; RESISTANCE VESSELS; ARTERY DISEASE; HEART-DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Lerman, A Mayo Clin & Mayo Fdn, Ctr Coronary Physiol & Imaging, Div Cardiovasc Dis, Dept Internal Med, 200 1st St SW, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 05 USA
Citazione:
S. Hamasaki et al., "Attenuated coronary flow reserve and vascular remodeling in patients with hypertension and left ventricular hypertrophy", J AM COL C, 35(6), 2000, pp. 1654-1660

Abstract

OBJECTIVES The purpose of this study was to evaluate the association between hypertension and left ventricular hypertrophy (LVH) with both coronary vascular remodeling and endothelial function. BACKGROUND The association between endothelial and nonendothelial coronaryflow reserve with vascular remodeling in patients with hypertension and LVI-I is still unclear. METHODS One hundred and eleven patients with normal or mildly diseased coronary arteries at angiography underwent intravascular ultrasound examination of the left anterior descending coronary artery. Patients were divided into three groups: group I: n = 13, hypertensive patients with LVH; group 2: n 30, hypertensive patients without LVH; group 3: n 68, normotensive patients. Vessel and lumen area and atherosclerotic plaque area were evaluated. Vascular reactivity was examined using intracoronary adenosine and acetylcholine. RESULTS Vessel area in group 1 (with LVH) was significantly (p < 0.01) greater than that in group 2 (without LVH), whereas, vessel area in both groups 1 and 3 was similar (12.8 +/- 0.8 mm(2), 10.7 +/- 0.4 mm(2) and 11.5 +/- 0.3 mm(2)). Coronary blood flow at baseline for patients in group 1 (with LVH) was significantly greater than it was for patients in groups 2 and 3 (81.1 +/- 9.9 ml/min, 56.5 +/- 6.2 ml/min and 48.1 +/- 3.2 ml/min, both p < 0.05). In comparison with groups 2 and 3, the response to both acetylcholineand adenosine was significantly impaired in patients with LVH. CONCLUSIONS The current study demonstrates that hypertension with LVH is associated with both coronary vascular remodeling and attenuated endothelialand nonendothelial coronary flow reserve. (C) 2000 by the American Collegeof Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 03:39:22