Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Regional myocardial blood flow in patients with sick sinus syndrome randomized to long-term single chamber atrial or dual chamber pacing - Effect of pacing mode and rate
Autore:
Nielsen, JC; Bottcher, M; Nielsen, TT; Pedersen, AK; Andersen, HR;
Indirizzi:
Aarhus Univ Hosp, Skejby Sygehus, Dept Cardiol B, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N t Cardiol B, DK-8200 Aarhus N, Denmark
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 6, volume: 35, anno: 2000,
pagine: 1453 - 1461
SICI:
0735-1097(200005)35:6<1453:RMBFIP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BUNDLE-BRANCH-BLOCK; POSITRON EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; LEFT-VENTRICULAR WALL; FOLLOW-UP; ACTIVATION SEQUENCE; HEART-FAILURE; FIBER STRAIN; CANINE HEART; N-13 AMMONIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Andersen, HR Aarhus Univ Hosp, Skejby Sygehus, Dept Cardiol B, Brendstrupgaardsvej, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Brendstrupgaardsvej Aarhus Denmark N enmark
Citazione:
J.C. Nielsen et al., "Regional myocardial blood flow in patients with sick sinus syndrome randomized to long-term single chamber atrial or dual chamber pacing - Effect of pacing mode and rate", J AM COL C, 35(6), 2000, pp. 1453-1461

Abstract

OBJECTIVES This study aimed to evaluate regional myocardial blood flow (MBF) and global left ventricular ejection fraction (LVEF) during chronic pacing in patients with sick sinus syndrome (SSS) randomized to either single chamber atrial (AAI) or dual chamber (DDD) pacing. BACKGROUND Experimental studies indicate that chronic pacing in the right ventricular apex changes regional MBF, thereby compromising left ventricular function. METHODS Thirty patients (age 74 +/- 10 years) were randomized to AAI (n = 15) or DDD (n = 15) pacemakers. After 22 +/- 7 months of pacing, MBF was quantified with N-13-labeled ammonia positron emission tomography scanning at60 beats per min and 90 beats per min. Patients in the DDD group furthermore underwent MBF measurement at temporary AAI pacing, 60 beats per min, Myocardial blood flow was assessed in the anterior, lateral, inferior and septal regions, and the global mean MBF was calculated. Left ventricular ejection fraction was determined by echocardiography at pacemaker implantation and at the time of MBF measurements. RESULTS Myocardial blood flow at rates 60 and 90 beats per min did not differ between the AAI and DDD groups. During temporary AAI pacing in the DDD group, MBF was significantly igher than during DDD pacing in both the inferior (p = 0.001) and septal (p = 0.004) regions and also globally (0.61 +/- 0.15 vs. 0.53 +/- 0.13 mL.g(-1).min(-1), p = 0.005). In the DDD group, LVEFdecreased from pacemaker implantation to time of MBF measurements (0.61 +/- 0.09 vs. 0.56 +/- 0.07, p = 0.013). Left ventricular ejection fraction during temporary AAI pacing at time of MBF measurements was not different from LVEF at pacemaker implantation. CONCLUSIONS In patients with SSS, chronic DDD pacing reduced inferior, septal and global mean MBF as well as LVEF, as compared with temporary AAI pacing. The LVEF reversed to baseline level during temporary AAI pacing despite 22 months of permanent ventricular pacing preceding it. Augmenting pace rate to 90 beats per min increased MF equally in the two treatment groups. (C) 2000 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:49:46