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Titolo:
Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder
Autore:
Perez, J; Tardito, D; Mori, S; Racagni, G; Smeraldi, E; Zanardi, R;
Indirizzi:
Univ Milan, Sch Med, Dept Neuropsychiat Sci, Ist Sci HSR, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 at Sci, Ist Sci HSR, I-20122 Milan, Italy Univ Milan, Inst Pharmacol Sci, Ctr Neuropharmacol, I-20122 Milan, Italy Univ Milan Milan Italy I-20122 Ctr Neuropharmacol, I-20122 Milan, Italy
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 2, volume: 34, anno: 2000,
pagine: 99 - 104
SICI:
0022-3956(200003/04)34:2<99:AREPAL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-A; SIGNAL-TRANSDUCTION; CYCLIC-AMP; MAP KINASE; MONONUCLEAR LEUKOCYTES; POSTMORTEM BRAIN; BINDING PROTEINS; MAJOR DEPRESSION; C ACTIVITY; B-RAF;
Keywords:
bipolar disorder; cAMP signaling; platelets; phosphorylation; Rap1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Perez, J Univ Milan, Sch Med, Dept Neuropsychiat Sci, Ist Sci HSR, I-20122Milan, Italy Univ Milan Milan Italy I-20122 st Sci HSR, I-20122 Milan, Italy
Citazione:
J. Perez et al., "Altered Rap1 endogenous phosphorylation and levels in platelets from patients with bipolar disorder", J PSYCH RES, 34(2), 2000, pp. 99-104

Abstract

Previous studies have reported abnormalities either in the cAMP-dependent endogenous phosphorylation or in the levels of Rap1 in platelets from bipolar patients, One limitation of these findings was that they come from different groups of patients in independent studies. To overcome this limitation, we designed the present study in which both these biochemicals parameterswere assessed in the same cohort of euthymic bipolar patients and healthy subjects. The results showed that the cAMP-dependent phosphorylation of Rap1 was significantly higher in platelets of bipolar patients with respect tohealthy subjects. Furthermore, immunoblotting experiments revealed that also the levels of Rap1 were significantly higher in bipolar patients than incontrol subjects, thus supporting that the abnormal phosphorylation can beascribed to the increased levels of Rap1. Taken together the results of the present study further support that downstream components of the cAMP signal cascade could be involved in the pathophysiology of bipolar disorders. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:02:20