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Titolo:
Effect of CGS 26303, an endothelin-converting enzyme-neutral endopeptidaseinhibitor, on nitrofen-induced congenital diaphragmatic hernia in the rat
Autore:
Kavanagh, M; Battistini, B; Kluth, D; Jean, S; Fournier, L; Jeng, AY; Major, D; Cloutier, R;
Indirizzi:
Univ Laval, Ctr Hosp, Anaesthesiol & Neonatal Invest Lab, CHUQ,CHUL, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada Univ Laval, Laval Hosp, Heart & Lung Inst, Quebec City, PQ G1V 4G2, CanadaUniv Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada Univ Hamburg Hosp, Dept Paediat Surg, D-2000 Hamburg, Germany Univ HamburgHosp Hamburg Germany D-2000 t Surg, D-2000 Hamburg, Germany Inst Natl Sante Publ Quebec, Ctr Expertise Depistage, Quebec City, PQ, Canada Inst Natl Sante Publ Quebec Quebec City PQ Canada uebec City, PQ, Canada Novartis Inst Biomed Res, Summit, NJ USA Novartis Inst Biomed Res Summit NJ USA s Inst Biomed Res, Summit, NJ USA
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 5, volume: 35, anno: 2000,
pagine: 780 - 784
SICI:
0022-3468(200005)35:5<780:EOC2AE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT PULMONARY-HYPERTENSION; VASOCONSTRICTOR PEPTIDE; DUAL INHIBITOR; ANIMAL-MODEL; LUNG; GLUCOCORTICOIDS; MANAGEMENT; NEWBORN; GROWTH;
Keywords:
congenital diaphragmatic hernia; endothelins; endothelin-converting enzyme; nitrofen; prenatal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Cloutier, R Univ Laval, Ctr Hosp, Anaesthesiol & Neonatal Invest Lab, CHUQ,CHUL, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 , PQ G1V 4G2, Canada
Citazione:
M. Kavanagh et al., "Effect of CGS 26303, an endothelin-converting enzyme-neutral endopeptidaseinhibitor, on nitrofen-induced congenital diaphragmatic hernia in the rat", J PED SURG, 35(5), 2000, pp. 780-784

Abstract

Background/Purpose: The pathophysiology of congenital diaphragmatic hernia(CDH) associated with lung hypoplasia and pulmonary hypertension is not understood fully. Endothelins (ETs) are the most potent vasoconstrictors thatalso act as promitogenic agents. They may play a role during pregnancy in leading to the condition found at birth and ongoing mortality in CDH. Therefore, the authors studied the effect of CGS 26303, a nonselective endothelin-converting enzyme and neutral endopeptidase inhibitor, in the rat model of CDH. Methods: Pregnant Sprague-Dawley rats were divided into 3 groups: group 1 (n = 4) received CGS 26303 (50 mg/kg, subcutaneously, twice a day), from gestational day 12 until term (21 to 23 days); group 2 (n = 8) received nitrofen (100 mg/kg, orally) at gestational day 11.5; group 3 (9 = 8) received both nitrofen and CGS 26303. The survival of the newborn rats was monitored up to 240 minutes. After natural death or euthanasia, they were weighed andmicrodissected. The degree of hernia was quantified as small, moderate, orsevere, and lungs and liver were harvested and weighed,Results: Newborn rats from mothers of group 3 (9 = 81) survived 196 +/- 8 minutes compared with 173 +/- 9 minutes of those of group 2 (9 = 97). Severs CDH from group 3 (n = 20) had a mean survival time of 66 +/- 13 minutes compared with 26 +/- 4 minutes for those of group 2 (9 = 27). Lung index in severe CDH pups of group 3 was increased by 13% compared with those from group 2 (P < .0001), whereas their liver index went down by 8% (P < .05). Conclusions These results suggest that CGS 26303 might have a beneficial effect when given during pregnancy in increasing survival at birth and reducing the severity of the pulmonary hypoplasia in newborn rats with nitrofen-induced CDH. Copyright (C) 2000 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:10:58