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Titolo:
Milk-borne insulin with trypsin inhibitor in milk induces pancreatic amylase development at the onset of weaning in rats
Autore:
Kinouchi, T; Koizumi, K; Kuwata, T; Yajima, T;
Indirizzi:
Meiji Milk Prod Co, Nutr Sci Inst, Dept Nutr Res, Lab Gastrointestinal Funct, Odawara 2500862, Japan Meiji Milk Prod Co Odawara Japan 2500862 l Funct, Odawara 2500862, Japan
Titolo Testata:
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
fascicolo: 5, volume: 30, anno: 2000,
pagine: 515 - 521
SICI:
0277-2116(200005)30:5<515:MIWTII>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-EPITHELIAL TRANSPORT; MESSENGER-RNA LEVELS; GENE-EXPRESSION; GROWTH-FACTOR; SUCKLING RAT; RECEPTOR GENE; GLUCOCORTICOIDS; PROTEIN; ILEUM; INCREASE;
Keywords:
artificial rearing; digestive function; milk-born insulin; weaning period;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yajima, T Meiji Milk Prod Co, Nutr Sci Inst, Dept Nutr Res, Lab Gastrointestinal Funct, 540 Naruda, Odawara 2500862, Japan Meiji Milk Prod Co 540 Naruda Odawara Japan 2500862 0862, Japan
Citazione:
T. Kinouchi et al., "Milk-borne insulin with trypsin inhibitor in milk induces pancreatic amylase development at the onset of weaning in rats", J PED GASTR, 30(5), 2000, pp. 515-521

Abstract

Background: The physiologic significance of milk-borne hormones and growthfactors for internal organs of suckling animals is poorly understood. In this study the significance of milk-borne insulin was evaluated, as well as its combination with trypsin inhibitor, and its role in the development of pancreatic digestive capacity at the time of weaning was investigated. Methods: Experiments were performed using insulin-deficient milk formula (standard formula), insulin (20 ng/ml) formula, or insulin with trypsin inhibitor (1 U/ml) formula by a rat artificial-rearing technique. Results: in 17-day-old rats administered standard formula, the plasma insulin level was as low as that in 14-day-old rats. When insulin-trypsin inhibitor formula was administered to rat pups, the plasma insulin level was significantly higher than those in rats given standard or insulin formula. In rats artificially reared on standard formula, the usual developmental increases in pancreatic amylase activity and plasma insulin concentration at thebeginning of weaning did not occur. Insulin formula elevated the pups' plasma insulin concentration and amylase activity at the onset of weaning but not to the levels observed in mother-reared rats. In rats reared on insulin-trypsin inhibitor formula, the developmental increases in the plasma insulin concentration and amylase activity observed in mother-reared rats were induced. Conclusions: The present study demonstrates the necessity of milk-borne insulin for the development of pancreatic amylase during the weaning period. (C) 2000 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 00:43:54