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Titolo:
Brain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 kinase-dependent pathway
Autore:
Righi, M; Tongiorgi, E; Cattaneo, A;
Indirizzi:
SISSA, Int Sch Adv Studies, Neurosci Program, I-34014 Trieste, Italy SISSA Trieste Italy I-34014 es, Neurosci Program, I-34014 Trieste, Italy Univ Trieste, Dept Biol, BRAIN Ctr Neurosci, I-34127 Trieste, Italy Univ Trieste Trieste Italy I-34127 Ctr Neurosci, I-34127 Trieste, Italy
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 20, anno: 2000,
pagine: 3165 - 3174
SICI:
0270-6474(20000501)20:9<3165:BNF(ID>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NERVE GROWTH-FACTOR; LOCAL PROTEIN-SYNTHESIS; SYNAPTIC ACTIVATION CAUSES; DEVELOPING RAT-BRAIN; IMMEDIATE-EARLY GENE; NGF MESSENGER-RNAS; PHOSPHOINOSITIDE 3-KINASE; SIGNAL-TRANSDUCTION; NEURITE OUTGROWTH;
Keywords:
dendritic mRNA; BDNF; TrkB; neurotrophins; PI3 kinase; intracellular pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Cattaneo, A SISSA, Int Sch Adv Studies, Neurosci Program, Via Beirut 2-4, I-34014 Trieste, Italy SISSA Via Beirut 2-4 Trieste Italy I-34014 014 Trieste, Italy
Citazione:
M. Righi et al., "Brain-derived neurotrophic factor (BDNF) induces dendritic targeting of BDNF and tyrosine kinase B mRNAs in hippocampal neurons through a phosphatidylinositol-3 kinase-dependent pathway", J NEUROSC, 20(9), 2000, pp. 3165-3174

Abstract

This study aims to understand the mechanisms of dendritic targeting of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) mRNAs. We show that brief depolarizations are sufficient to induce accumulation of BDNF and TrkB mRNAs in dendrites of hippocampal neurons. Endogenous BDNF, secreted during the KCl stimulation, contributes significantly to the dendritic accumulation of BDNF-TrkB mRNAs. In the absence of depolarization, 1 min pulses of exogenous BDNF are sufficient to induce dendritic accumulation of BDNF-TrkB mRNAs. After binding to TrkB, BDNF exerts this action by activating a PI-3 kinase-dependent pathway. The accumulation of dendritic mRNA by BDNF is not mediated by BDNF-induced neurotransmitter release. Because most hippocampal neurons coexpress BDNF and TrkB receptors, these results show that the subcellular distribution of BDNF-TrkB mRNAs is under the controlof an autocrine-paracrine BDNF-TrkB-dependent loop.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 05:49:11