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Titolo:
NMDA receptor activity in utero averts respiratory depression and anomalous long-term depression in newborn mice
Autore:
Poon, CS; Zhou, ZG; Champagnat, J;
Indirizzi:
MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139 iv Hlth Sci & Technol, Cambridge, MA 02139 USA CNRS, F-91198 Gif Sur Yvette, France CNRS Gif Sur Yvette France F-91198CNRS, F-91198 Gif Sur Yvette, France
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 9, volume: 20, anno: 2000,
pagine: RC731 - NIL_9
SICI:
0270-6474(20000501)20:9<RC731:NRAIUA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT SYNAPTIC PLASTICITY; D-ASPARTATE RECEPTORS; MOLECULAR DIVERSITY; CAROTID CHEMOREFLEX; BRAIN; ANTAGONISTS; BLOCKADE; NEURONS; DISRUPTION; MODULATION;
Keywords:
NMDA receptor; NR1 knock-out; synaptic longterm depression; respiratory failure; nucleus tractus solitarius; prenatal neural development; newborn mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Poon, CS MIT, Harvard Mit Div Hlth Sci & Technol, Bldg E25-501, Cambridge,MA 02139USA MIT Bldg E25-501 Cambridge MA USA 02139 1, Cambridge, MA 02139USA
Citazione:
C.S. Poon et al., "NMDA receptor activity in utero averts respiratory depression and anomalous long-term depression in newborn mice", J NEUROSC, 20(9), 2000, pp. RC731-NIL_9

Abstract

Mutant mice lacking NMDA receptor 1 subunit (NR1) showed marked depressionof respiratory and suckling activities in vivo and overexpression of synaptic long-term depression (LTD) in a brainstem cardiorespiratory-related region (nucleus tractus solitarius) in vitro. Pharmacological blockade of NMDAreceptors in normal newborn mice mimicked the depression in suckling activity but not respiratory depression in vivo or brainstem LTD in vitro. Results at the behavioral and cellular levels demonstrate that NMDA receptor deficiency during prenatal development may unleash an anomalous form of NMDA receptor-independent LTD along with life-threatening respiratory depression consequences in the newborn. These findings raise the specter of cardiorespiratory dysregulation with increased risks of morbidity and mortality in the infant as a result of premature births or genetic or drug-induced NMDA receptor antagonism during pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:56:56