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Titolo:
Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and coagulation factor VII Arg353 -> Gln polymorphism in Korean patients with coronary artery disease
Autore:
Song, J; Yoon, YM; Jung, HJ; Hong, SH; Park, H; Kim, JQ;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Clin Pathol, Chongno Gu, Seoul 110744, South Korea Seoul Natl Univ Seoul South Korea 110744 o Gu, Seoul 110744, South Korea Sung Kyun Kwan Univ, Sch Med, Seoul, South Korea Sung Kyun Kwan Univ Seoul South Korea Univ, Sch Med, Seoul, South Korea
Titolo Testata:
JOURNAL OF KOREAN MEDICAL SCIENCE
fascicolo: 2, volume: 15, anno: 2000,
pagine: 146 - 152
SICI:
1011-8934(200004)15:2<146:PAI4PP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIC HEART-DISEASE; MYOCARDIAL-INFARCTION; GENETIC-POLYMORPHISM; PAI-1 GENE; DIABETIC-RETINOPATHY; ANTIGEN LEVELS; PIMA-INDIANS; PLASMA; THROMBOSIS; RISK;
Keywords:
plasminogen activator inhibitor 1; factor VII; polymorphism (genetics); coronary disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, JQ Seoul Natl Univ, Coll Med, Dept Clin Pathol, Chongno Gu, 28 YongonDong, Seoul 110744, South Korea Seoul Natl Univ 28 Yongon Dong Seoul South Korea 110744 uth Korea
Citazione:
J. Song et al., "Plasminogen activator inhibitor-1 4G/5G promoter polymorphism and coagulation factor VII Arg353 -> Gln polymorphism in Korean patients with coronary artery disease", J KOR MED S, 15(2), 2000, pp. 146-152

Abstract

An increased risk for arterial thrombosis is associated with high plasma levels of coagulation and fibrinolytic factors such as PAI-1 and FVII. In this study, the 4G/5G polymorphism in the promoter of PAI-1 gene and Arg353-->Gln polymorphism in the FVII gene were analysed in 139 normal adults and 158 patients with coronary artery disease (CAD), and their association with plasma lipid traits was investigated. There were no significant differencesin the allele frequencies of PAI-I and FVII polymorphisms between control and patient groups. The allelic distributions of both polymorphisms in Koreans were similar to those in Japanese but significantly different from those in Caucasians. in the CAD group, the 4G homozygotes of PAI-1 polymorphismshowed significantly higher levels of total (p=0.0250) and LDL cholesterol(p=0.0335) with individuals having other genotypes. However, FVII polymorphism showed no association with lipid levels. In conclusion, the 4G/5G PAI-1 promoter polymorphism and Arg353-->Gln Nil polymorphism are not major genetic risk factors for CAD in Koreans. However, 4G allele of PAI-1 polymorphism revealed to be associated with the levels of cholesterol, especially LDL cholesterol levels in CAD patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:49:59