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Titolo:
Linkage of mood disorders with D2, D3 and TH genes: a multicenter study
Autore:
Serretti, A; Macciardi, F; Cusin, C; Lattuada, E; Souery, D; Lipp, O; Mahieu, B; Van Broeckhoven, C; Blackwood, D; Muir, W; Aschauer, HN; Heiden, AM; Ackenheil, M; Fuchshuber, S; Raeymaekers, P; Verheyen, G; Kaneva, R; Jablensky, A; Papadimitriou, GN; Dikeos, DG; Stefanis, CN; Smeraldi, E; Mendlewicz, J;
Indirizzi:
Univ Milan, Osped San Raffaele, Sch Med,Ist Sci, Dept Neuropsychiat Sci, I-20127 Milan, Italy Univ Milan Milan Italy I-20127 t Neuropsychiat Sci, I-20127 Milan, Italy Free Univ Brussels, Erasme Hosp, Clin Brussels, Dept Psychiat, B-1050 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1050 iat, B-1050 Brussels, Belgium Univ Antwerp, Born Bunge Fdn, Flanders Interuniv Inst Biotechnol, Inst Biotechnol,Dept Biochem,Lab Neurogenet, B-2020 Antwerp, Belgium Univ Antwerp Antwerp Belgium B-2020 Neurogenet, B-2020 Antwerp, Belgium Univ Edinburgh, Dept Psychiat, Edinburgh EH8 9YL, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9YL Midlothian, Scotland Western Gen Hosp, Human Genet Unit, MRC, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland Univ Hosp Psychiat, Dept Gen Psychiat, Vienna, Austria Univ Hosp PsychiatVienna Austria t, Dept Gen Psychiat, Vienna, Austria Univ Munich, Hosp Psychiat, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 Hosp Psychiat, D-8000 Munich, Germany Univ Western Australia, Dept Psychiat, Perth, WA 6009, Australia Univ Western Australia Perth WA Australia 6009 Perth, WA 6009, Australia Univ Athens, Sch Med, Dept Psychiat, GR-11527 Athens, Greece Univ Athens Athens Greece GR-11527 ept Psychiat, GR-11527 Athens, Greece Univ Athens, Mental Hlth Res Inst, Athens, Greece Univ Athens Athens Greece Athens, Mental Hlth Res Inst, Athens, Greece
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1, volume: 58, anno: 2000,
pagine: 51 - 61
SICI:
0165-0327(200004)58:1<51:LOMDWD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; TYROSINE-HYDROXYLASE GENE; MANIC-DEPRESSIVE ILLNESS; DOPAMINE-D2 RECEPTOR GENES; OLD ORDER AMISH; CLOSE LINKAGE; NO EVIDENCE; GABAERGIC NEUROTRANSMISSION; AUSTRALIAN PEDIGREES; MAJOR LOCUS;
Keywords:
dopamine receptors; DRD2; DRD3; tyrosine hydroxylase; linkage; bipolar disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Serretti, A Univ Milan, Osped San Raffaele, Sch Med,Ist Sci, Dept Neuropsychiat Sci, Via Luigi Prinetti 29, I-20127 Milan, Italy Univ Milan Via LuigiPrinetti 29 Milan Italy I-20127 n, Italy
Citazione:
A. Serretti et al., "Linkage of mood disorders with D2, D3 and TH genes: a multicenter study", J AFFECT D, 58(1), 2000, pp. 51-61

Abstract

Background: It has been suggested that the dopaminergic system is involvedin the pathophysiology of mood disorders. We conducted a multicenter studyof families with mood disorders, to investigate a possible linkage with genes coding for dopamine receptor D2, dopamine receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood disorder pedigrees collected within the framework of the European Collaborative Project on Affective Disorders were analyzed with parametric and non-parametric linkage methods. Variouspotential phenotypes were considered, from a narrow (only bipolar as affected) to a broad (bipolar + major depressive + schizoaffective disorders) definition of affection status. Results: Parametric analyses excluded linkagefor all the candidate genes, even though small positive LOD (Limit of Detection) scores were observed for TH in three families. Non-parametric analyses yielded negative results for all markers. Conclusion: The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 27/01/20 alle ore 07:25:06