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Titolo:
A physical model for dual-energy x-ray absorptiometry-derived bone mineraldensity
Autore:
Sievanen, H;
Indirizzi:
UKK Inst, Bone Res Grp, FIN-33501 Tampere, Finland UKK Inst Tampere Finland FIN-33501 e Res Grp, FIN-33501 Tampere, Finland
Titolo Testata:
INVESTIGATIVE RADIOLOGY
fascicolo: 5, volume: 35, anno: 2000,
pagine: 325 - 330
SICI:
0020-9996(200005)35:5<325:APMFDX>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE COMPUTED-TOMOGRAPHY; BODY COMPRESSIVE STRENGTH; PROXIMAL FEMUR; VERTEBRAL BODY; IN-VITRO; FAILURE LOADS; DENSITOMETRY; PREDICTION; DXA; ULTRASOUND;
Keywords:
bone mineral density; bone strength; computed; tomography; osteoporosis; X-ray absorptiometry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sievanen, H UKK Inst, Bone Res Grp, POB 30, FIN-33501 Tampere, Finland UKKInst POB 30 Tampere Finland FIN-33501 01 Tampere, Finland
Citazione:
H. Sievanen, "A physical model for dual-energy x-ray absorptiometry-derived bone mineraldensity", INV RADIOL, 35(5), 2000, pp. 325-330

Abstract

RATIONALE AND OBJECTIVES. Dual-energy X-ray absorptiometry (DXA)-derived areal bone mineral density (BMD) is an established predictor of osteoporoticfractures and reflects bone strength as well, The goal of this study was to develop and validate a physical model for appropriate interpretation of BMD. METHODS. DXA and peripheral quantitative computed tomography investigations of the distal tibia (n = 45), proximal tibia (n = 12), distal femur (n = 26), and distal radius (n = 34) were carried out. The DXA-derived BMD was analytically modeled as a nonlinear function of volumetric bone mineral apparent density and the cross-sectional area (eCSA) of given bone; ie, BMDmod = apparent BMD x root eCSA. RESULTS. At every measured skeletal site, the relationship between BMD andBMDmod was systematically stronger than that observed separately between BMD and apparent BMD or cross-sectional area. The models (r(2)) explained 85%, 94%, 87%, and 74% of the variability in BMD at the distal tibia, proximal tibia, distal femur, and distal radius, respectively,CONCLUSIONS. The mutual contributions of bone density and size to BMD can vary to some extent in a site-dependent fashion, This dual nature of BMD onone hand provides a reasonable mechanical explanation for why BMD is a good surrogate of bone strength and a predictor of osteoporotic fractures but on the other hand, complicates its detailed interpretation.

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Documento generato il 29/11/20 alle ore 16:24:52