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Titolo:
ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels
Autore:
Neale, MC; de Knijff, P; Havekes, LM; Boomsma, DI;
Indirizzi:
Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Leiden Univ, MGC Dept Human Genet, Leiden, Netherlands Leiden Univ Leiden Netherlands GC Dept Human Genet, Leiden, Netherlands TNO Prevent & HLth, Gaubius Lab, Leiden, Netherlands TNO Prevent & HLth Leiden Netherlands Gaubius Lab, Leiden, Netherlands Vrije Univ Amsterdam, Dept Physiol Psychol, Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands chol, Amsterdam, Netherlands
Titolo Testata:
GENETIC EPIDEMIOLOGY
fascicolo: 4, volume: 18, anno: 2000,
pagine: 331 - 340
SICI:
0741-0395(200004)18:4<331:APAFOP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E POLYMORPHISM; PLASMA-LEVELS; PARENT-TWIN; E PHENOTYPE; ATHEROSCLEROSIS; LIPOPROTEIN; DISEASE; SEX; AGE;
Keywords:
ApoE locus; apoC1 locus; ApoG level; twins; parents; variation; Mx;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Neale, MC Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Box 980126, Richmond, VA 23298 USA Virginia Commonwealth Univ Box 980126 Richmond VA USA 23298 USA
Citazione:
M.C. Neale et al., "ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels", GENET EPID, 18(4), 2000, pp. 331-340

Abstract

ApoE levels and chromosome 19 ApoE polymorphisms were measured in a sampleof 156 Dutch families. Each pedigree consisted of parents aged 35-65 yearsand their twin offspring aged 14-21 years. A significant effect of the chromosome 19 apoE locus on quantitative plasma levels of apolipoprotein E wasobserved. The ApoE polymorphism explained 16% of the variance in ApoE levels. Tests of association of ApoE levels with the apoC1 locus, which is in complete linkage disequilibrium with the ApoE locus, also showed a significant effect, although the variance explained by ApoC1 was only 1%. Examination of the covariance between twins classified according to allele sharing indicates that the association is not due to population stratification, but to a genuine effect of the ApoE locus on levels. However, the ApoE locus accounts for only one-fourth of the genetic variation in ApoE levels. (C) 2000Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:09:19