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Titolo:
Improvement by low doses of nociceptin on scopolamine-induced impairment of learning and/or memory
Autore:
Hiramatsu, M; Inoue, K;
Indirizzi:
Meijo Univ, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tenpaku Ku, Nagoya, Aichi 4688503, Japan Meijo Univ Nagoya Aichi Japan 4688503 ku Ku, Nagoya, Aichi 4688503, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 395, anno: 2000,
pagine: 149 - 156
SICI:
0014-2999(20000428)395:2<149:IBLDON>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DELAYED AMNESIA; LONG-TERM POTENTIATION; OPIOID RECEPTOR; ORPHANIN-FQ; NALOXONE BENZOYLHYDRAZONE; ACETYLCHOLINE-RELEASE; DYNORPHIN A-(1-13); MICE; BRAIN; RAT;
Keywords:
nocistatin; naloxone benzoylhydrazone; kappa-opioid receptor; spontaneous alternation; passive avoidance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Hiramatsu, M Meijo Univ, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tenpaku Ku, 150 Yagotoyama, Nagoya, Aichi 4688503, Japan Meijo Univ 150 Yagotoyama Nagoya Aichi Japan 4688503 3, Japan
Citazione:
M. Hiramatsu e K. Inoue, "Improvement by low doses of nociceptin on scopolamine-induced impairment of learning and/or memory", EUR J PHARM, 395(2), 2000, pp. 149-156

Abstract

The effects of fmol doses of nociceptin/orphanin FQ on scopolamine-inducedimpairment of learning and/or memory were examined using spontaneous alternation of Y-maze and step-down type passive avoidance tasks. While fmol doses of nociceptin alone had no effect on spontaneous alternation or passive avoidance behavior in normal mice, administration of nociceptin (10 and/or 100 fmol/mouse) 30 min before spontaneous alternation performance or the training session of the passive avoidance task, significantly improved the scopolamine-induced impairment of spontaneous alternation and passive avoidance behavior. This ameliorating effect was not antagonized by nocistatin (0.5 and 5.0 nmol/mouse, i.c.v.), naloxone benzoylhydrazone (2.3, 11.2, and 56.1 mu mol/kg, s.c.) or nor-binaltorphimine (4.9 nmol/mouse, i.c.v.). These results indicated that very low doses of nociceptin ameliorate impairments of spontaneous alternation and passive avoidance induced by scopolamine, and suggested that this peptide has bidirectional modulatory effects on learning and memory; impairment at high doses and amelioration at low doses. (C)2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:59:50