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Titolo:
Effects of circadian regulation and rest-activity state on spontaneous seizures in a rat model of limbic epilepsy
Autore:
Quigg, M; Clayburn, H; Straume, M; Menaker, M; Bertram, EH;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Neurol, Comprehens Epilepsy Program, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Natl Sci Fdn, Ctr Biol Timing, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Biol, Charlottesville, VA 22908 USA UnivVirginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Hlth Sci Ctr, Dept Med, Div Endocrinol, Charlottesville, VA22908 USA Univ Virginia Charlottesville VA USA 22908 , Charlottesville, VA22908 USA
Titolo Testata:
EPILEPSIA
fascicolo: 5, volume: 41, anno: 2000,
pagine: 502 - 509
SICI:
0013-9580(200005)41:5<502:EOCRAR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLONIDINE SUPPRESSES SEIZURES; INTERICTAL SPIKING INCREASES; IDAZOXAN PROMOTES SEIZURES; AMYGDALA-KINDLED KITTENS; TEMPORAL-LOBE EPILEPSY; SLEEP-WAKE STATES; STATUS EPILEPTICUS; SUPRACHIASMATIC NUCLEI; PONTINE MICROINFUSION; HIPPOCAMPAL SEIZURES;
Keywords:
chronobiology; circadian rhythms; epilepsy; hypothalamus; thermoregulation; mesial temporal lobe epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Quigg, M Univ Virginia, Hlth Sci Ctr, Dept Neurol, Comprehens Epilepsy Program, Box394, Charlottesville, VA 22908 USA Univ Virginia Box 394 Charlottesville VA USA 22908 , VA 22908 USA
Citazione:
M. Quigg et al., "Effects of circadian regulation and rest-activity state on spontaneous seizures in a rat model of limbic epilepsy", EPILEPSIA, 41(5), 2000, pp. 502-509

Abstract

Purpose: Circadian regulation via the suprachiasmatic nuclei and rest-activity state may influence expression of limbic seizures. Methods: Male rats (n = 14) were made epileptic by electrical stimulation of the hippocampus, causing limbic status epilepticus and subsequent seizures. We monitored seizures with intrahippocampal electrodes in 12-12-h light/dark (LD) cycles and in continuous dark (DD). We used radiotelemetry monitoring of activity to measure state and body temperature to determine circadian phase. Cosinor analysis and chi(2) tests determined whether seizures occurred rhythmically when plotted by phase. State was defined as inactive oractive in 10-min epochs based on whether activity count was below or abovea cut-off value validated from video observation. Results: In LD, the peak seizure occurrence was 14:59 h after circadian temperature peak (95% confidence limit, 13:37-16:19). Phasic seizure occurrence persisted in DD for 14:05 (12:31-15:38), p < 0.0001, against uniform mean distribution. In LD, 14,787 epochs contained 1,268 seizures: seizures preferentially occurred during inactive epochs (965 observed, 878 expected in proportion to the overall distribution of inactive versus active epochs: p < 0.001). In DD, 20,664 epochs contained 1,609 seizures; seizures had no preferential occurrence by state (999 observed, 1,025 expected; p = 0.16). Conclusions: Limbic seizures occurred with an endogenous circadian rhythm. Seizures preferentially struck during inactivity during entrainment to thelight-dark cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:34:41