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Titolo:
Cholera toxin-induced secretion in rats is reduced by a soluble fiber, gumArabic
Autore:
Turvill, JL; Wapnir, RA; Wingertzahn, MA; Teichberg, S; Farthing, MJG;
Indirizzi:
St Bartholomews & Royal London Sch Med & Dent, Digest Dis Res Ctr, London E1 2AD, England St Bartholomews & Royal London Sch Med & Dent London England E1 2AD land NYU, Sch Med, N Shore Univ Hosp, Dept Pediat, Manhasset, NY USA NYU Manhasset NY USA , N Shore Univ Hosp, Dept Pediat, Manhasset, NY USA NYU, Sch Med, N Shore Univ Hosp, Dept Labs, Manhasset, NY USA NYU Manhasset NY USA ed, N Shore Univ Hosp, Dept Labs, Manhasset, NY USA
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 5, volume: 45, anno: 2000,
pagine: 946 - 951
SICI:
0163-2116(200005)45:5<946:CTSIRI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ORAL REHYDRATION SOLUTIONS; SODIUM-ABSORPTION; ACUTE DIARRHEA; OSMOTIC DIARRHEA; PEPTIDE YY; MODEL; WATER; RICE; THERAPY; EFFICACY;
Keywords:
cholera toxin; oral rehydration solutions; gum arabic; intestine; sodium transport; water transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Turvill, JL St Bartholomews & Royal London Sch Med & Dent, Digest Dis Res Ctr, 2 Turner St, London E1 2AD, England St Bartholomews & Royal London SchMed & Dent 2 Turner St London England E1 2AD
Citazione:
J.L. Turvill et al., "Cholera toxin-induced secretion in rats is reduced by a soluble fiber, gumArabic", DIG DIS SCI, 45(5), 2000, pp. 946-951

Abstract

Gum arabic (GA), a soluble fiber with emulsifying properties, enhances intestinal water and electrolyte absorption in normal and secreting rats. Our aim was to assess the effect of GA, 2.5 and 5.0 g/liter, on cholera toxin-induced water and electrolyte secretion in rat jejunum in vivo. After a 2-hrexposure to cholera toxin. jejunal segments of adult rats were perfused invivo with a plasma electrolyte solution containing GA, 0, 2.5 or 5.0 g/liter. Na-24 was used as a marker of sodium influx. Cholera toxin-induced secretion was reduced by GA, 2.5 and 5.0 g/liter. Na-24 secretion into the lumen was reduced by GA. GA caused a morphological expansion of intercellular spaces in the villi but not crypts. In conclusion, GA promotes lumen to blood intestinal transport of water and sodium despite cholera toxin activation. These observations support a potential role for GA in enhancing the efficacy of ORS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:10:50