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Titolo:
Hypersecretory duodenal ulcer and Helicobacter pylori infection: a four-year follow-up study
Autore:
Capurso, G; Martino, G; Grossi, C; Annibale, B; Delle Fave, G;
Indirizzi:
Univ Rome La Sapienza, Policlin Umberto I, Med Clin 2, Dipartimento Gastroenterol, I-00161 Rome, Italy Univ Rome La Sapienza Rome Italy I-00161 troenterol, I-00161 Rome, Italy
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 2, volume: 32, anno: 2000,
pagine: 119 - 124
SICI:
1590-8658(200003)32:2<119:HDUAHP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZOLLINGER-ELLISON SYNDROME; GASTRIC-ACID SECRETION; C-13-UREA BREATH TEST; CELL HYPERFUNCTION; PEPTIC-ULCER; ERADICATION; LANSOPRAZOLE; DISEASE; BASAL; PENTAGASTRIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Annibale, B Univ Rome La Sapienza, Policlin Umberto I, Med Clin 2, Dipartimento Gastroenterol, Viale Policlin 5, I-00161 Rome, Italy Univ Rome La Sapienza Viale Policlin 5 Rome Italy I-00161 aly
Citazione:
G. Capurso et al., "Hypersecretory duodenal ulcer and Helicobacter pylori infection: a four-year follow-up study", DIG LIVER D, 32(2), 2000, pp. 119-124

Abstract

Background. About 10% of duodenal ulcer patients are characterized by gastric acid hypersecretion with normal gastrin values. Relapsing duodenal ulcer after Helicobacter pylori cure has been related to high acid output and maintenance antisecretory therapy has been suggested in hypersecretory duodenal ulcer patients. The role of Helicobacter pylori infection and the effects of Helicobacter pylori cure in hypersecretory duodenal ulcer patients still remain to be fully studied. Aim. To study: a) whether gastric acid hypersecretion "per se" is a risk factor for duodenal ulcer recurrence; bl whether maintenance antisecretory therapy is necessary after eradication in hypersecretory duodenal ulcer patients. Patients. The study population comprised 8 hypersecretory duodenal ulcer patients, selected from a population of 79 Helicobacter pylori-positive duodenal ulcer patients. Methods. Hypersecretory duodenal ulcer patients were followed-up for at least 4 years after eradication. Gastric acid secretion was measured again 12months after Helicobacter pylori eradication. Gastroscopy with histology was performed 3, 6, 12 and 36 months after treatment, (13)G-urea breath testafter 42 months; clinical questionnaires were completed every 6 months. Results. After eradication, despite a not significantly reduced high acid output (median value of basal acid output and pentagastrin-stimulated acid output, respectively, 23.1 mEq/h and 64.1 mEq/h before treatment vs 16 mEq/h and 49.7 mEq/h 12 months after treatment), all patients were free from symptoms, none of them had duodenal ulcer relapse or complications (7/8 before treatment), or needed antisecretory maintenance therapy, except for one patient taking non-steroidal anti-inflammatory drugs. Conclusions. These findings, obtained in a selected population of hypersecretory duodenal ulcer patients with long-term follow-up, suggest that aftersuccessful Helicobacter pylori eradication gastric acid hypersecretion "per se" is not able to determine the recurrence of duodenal ulcer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:05:59