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Titolo:
Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA alpha orphan receptor
Autore:
Chomez, P; Neveu, I; Mansen, A; Kiesler, E; Larsson, L; Vennstrom, B; Arenas, E;
Indirizzi:
Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Biol, S-17177 Stockholm, Sweden Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 phys, S-17177 Stockholm, Sweden Karolinska Hosp, Dept Clin Neurophysiol, S-17176 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-17176 siol, S-17176 Stockholm, Sweden
Titolo Testata:
DEVELOPMENT
fascicolo: 7, volume: 127, anno: 2000,
pagine: 1489 - 1498
SICI:
0950-1991(200004)127:7<1489:ICDADD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR RECEPTOR; PURKINJE-CELLS; ROR-ALPHA; RESPONSE ELEMENT; OPPOSITE STRAND; MONOMER-BINDING; GENE; EXPRESSION; DIFFERENTIATION; DOMAINS;
Keywords:
orphan nuclear receptor; cerebellar development; knockout mice; rev-erbA alpha gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Arenas, E Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, SwedenKarolinska Inst Stockholm Sweden S-17177 177 Stockholm, Sweden
Citazione:
P. Chomez et al., "Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA alpha orphan receptor", DEVELOPMENT, 127(7), 2000, pp. 1489-1498

Abstract

The rev-erbA alpha gene, belonging to the steroid receptor superfamily of transcription factors, is highly conserved during evolution but little is known so far about its functions in development or in adult physiology, Here, we describe genetically altered mice lacking the rev-erbAa gene. These animals do not show any obvious phenotype in either fat tissue or skeletal muscle, despite the known regulation of rev-erbAa expression during adipocyteand myotube differentiation in vitro. However, during the second week of life, the cerebellum of rev-erbA alpha mutants presents several unexpected abnormalities, such as alterations in the development of Purkinje cells, delay in the proliferation and migration of granule cells from the external granule cell layer and increased apoptosis of neurons in the internal granulecell layer. Interestingly, the expression pattern of rev-erbA alpha suggests that the abnormalities observed in the external granule cell layer couldbe secondary to Purkinje cell alterations. Taken together, our data underline the importance of rev-erbAa expression for the appropriate balance of transcriptional activators and repressors during postnatal cerebellar development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 19:23:39